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bcsA cellulose synthase catalytic subunit [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 948053, updated on 3-Dec-2024

Summary

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Official Symbol
bcsA
Official Full Name
cellulose synthase catalytic subunit
Primary source
ECOCYC:EG12260
Locus tag
b3533
See related
ASAP:ABE-0011547
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK3518; yhjO; yhjP
Summary
BcsA has a C-terminal PilZ domain, which has been implicated in cyclic-di-GMP binding to YcgR. [More information is available at EcoGene: EG12260]. BcsA, BcsB, BcsZ and BcsC are involved in biosynthesis of cellulose, a characteristic of the rdar morphotype . [More information is available at EcoCyc: EG12260].
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Genomic context

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Sequence:
NC_000913.3 (3692618..3695236, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene cellulose synthase outer membrane channel Neighboring gene endo-1,4-D-glucanase Neighboring gene cellulose synthase periplasmic subunit Neighboring gene pseudo Neighboring gene PF10945 family protein YhjR Neighboring gene c-di-GMP-binding protein BcsE Neighboring gene putative cellulose biosynthesis protein BcsF

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Architecture of the Cellulose Synthase Outer Membrane Channel and Its Association with the Periplasmic TPR Domain. Acheson JF, et al. Structure, 2019 Dec 3. PMID 31604608, Free PMC Article
  2. Cellulose as an architectural element in spatially structured Escherichia coli biofilms. Serra DO, et al. J Bacteriol, 2013 Dec. PMID 24097954, Free PMC Article
  3. Cellulose modulates biofilm formation by counteracting curli-mediated colonization of solid surfaces in Escherichia coli. Gualdi L, et al. Microbiology (Reading), 2008 Jul. PMID 18599830
  4. Tight modulation of Escherichia coli bacterial biofilm formation through controlled expression of adhesion factors. Da Re S, et al. Appl Environ Microbiol, 2007 May. PMID 17384304, Free PMC Article
  5. Crl activates transcription initiation of RpoS-regulated genes involved in the multicellular behavior of Salmonella enterica serovar Typhimurium. Robbe-Saule V, et al. J Bacteriol, 2006 Jun. PMID 16707690, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables cellulose synthase (UDP-forming) activity IEA
Inferred from Electronic Annotation
more info
  
enables cellulose synthase activity IEA
Inferred from Electronic Annotation
more info
  
enables cyclic-di-GMP binding IEA
Inferred from Electronic Annotation
more info
  
enables glycosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables hexosyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in UDP-alpha-D-glucose metabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within bacterial cellulose biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cellulose biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
cellulose synthase catalytic subunit
NP_417990.4

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    3692618..3695236 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_417990.4 cellulose synthase catalytic subunit [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_417990.4

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A776LWK4
    Conserved Domains (1) summary
    PRK11498
    Location:15 → 865
    bcsA; cellulose synthase catalytic subunit; Provisional
Nucleotide Protein
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