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ftsX cell division protein FtsX [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 947969, updated on 17-Dec-2024

Summary

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Official Symbol
ftsX
Official Full Name
cell division protein FtsX
Primary source
ECOCYC:EG10345
Locus tag
b3462
See related
ASAP:ABE-0011311
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK3446; ftsS
Summary
Overexpression causes filamentous biofilm formation. [More information is available at EcoGene: EG10345]. FtsX is the putative membrane component of an ATP-binding cassette (ABC) transporter . [More information is available at EcoCyc: EG10345].
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Genomic context

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Sequence:
NC_000913.3 (3601028..3602086, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene branched chain amino acid/phenylalanine ABC transporter periplasmic binding protein Neighboring gene RNA polymerase sigma factor RpoH Neighboring gene cell division protein FtsE Neighboring gene signal recognition particle receptor Neighboring gene 16S rRNA m(2)G966 methyltransferase Neighboring gene DUF1145 domain-containing protein YhhL

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Division behavior and shape changes in isogenic ftsZ, ftsQ, ftsA, pbpB, and ftsE cell division mutants of Escherichia coli during temperature shift experiments. Taschner PE, et al. J Bacteriol, 1988 Apr. PMID 3280547, Free PMC Article
  2. Genetic analysis of essential genes in the ftsE region of the Escherichia coli genetic map and identification of a new cell division gene, ftsS. Salmond GP, et al. Mol Gen Genet, 1984. PMID 6394955
  3. The identification of the Escherichia coli ftsY gene product: an unusual protein. Gill DR, et al. Mol Microbiol, 1990 Apr. PMID 2161989
  4. FtsEX acts on FtsA to regulate divisome assembly and activity. Du S, et al. Proc Natl Acad Sci U S A, 2016 Aug 23. PMID 27503875, Free PMC Article
  5. An ATP-binding cassette transporter-like complex governs cell-wall hydrolysis at the bacterial cytokinetic ring. Yang DC, et al. Proc Natl Acad Sci U S A, 2011 Nov 8. PMID 22006326, Free PMC Article

See all (30) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Roles of ATP Hydrolysis by FtsEX and Interaction with FtsA in Regulation of Septal Peptidoglycan Synthesis and Hydrolysis.
    Title: Roles of ATP Hydrolysis by FtsEX and Interaction with FtsA in Regulation of Septal Peptidoglycan Synthesis and Hydrolysis.
  2. FtsEX first interacts with FtsZ to localize to the Z ring and then interacts with FtsA to promote divisome assembly and regulate septal peptidoglycan synthesis.
    Title: How FtsEX localizes to the Z ring and interacts with FtsA to regulate cell division.
  3. FtsEX acts on FtsA to regulate both divisome assembly and activity.
    Title: FtsEX acts on FtsA to regulate divisome assembly and activity.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in FtsZ-dependent cytokinesis NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in cell division IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in cell division IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within cell division IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cell division NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in division septum assembly NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in peptidoglycan turnover NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in positive regulation of cell division IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
part_of ATPase complex IPI
Inferred from Physical Interaction
more info
 PubMed 
located_in Gram-negative-bacterium-type cell wall IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cell division site IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cell division site IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cell division site NAS
Non-traceable Author Statement
more info
 PubMed 
located_in division septum IDA
Inferred from Direct Assay
more info
 PubMed 
part_of divisome complex NAS
Non-traceable Author Statement
more info
 PubMed 
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane NAS
Non-traceable Author Statement
more info
 PubMed 
part_of plasma membrane protein complex IPI
Inferred from Physical Interaction
more info
 PubMed 

General protein information

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Preferred Names
cell division protein FtsX

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    3601028..3602086 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_417919.1 cell division protein FtsX [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_417919.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A829KWZ0, A0AAN3MB91
    Conserved Domains (1) summary
    PRK11026
    Location:44 → 352
    ftsX; cell division ABC transporter subunit FtsX; Provisional
Nucleotide Protein
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