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mlaB intermembrane phospholipid transport system protein MlaB [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 947954, updated on 3-Dec-2024

Summary

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Official Symbol
mlaB
Official Full Name
intermembrane phospholipid transport system protein MlaB
Primary source
ECOCYC:G7658
Locus tag
b3191
See related
ASAP:ABE-0010487
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK3180; yrbB
Summary
The STAS domain is found in sulfate transporters and anti-sigmas and may bind NTPs. [More information is available at EcoGene: EG12797].
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Genomic context

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Sequence:
NC_000913.3 (3336963..3337256, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene UDP-N-acetylglucosamine 1-carboxyvinyltransferase Neighboring gene acid stress protein IbaG Neighboring gene intermembrane phospholipid transport system - periplasmic binding protein Neighboring gene intermembrane phospholipid transport system, substrate binding protein MlaD Neighboring gene intermembrane phospholipid transport system, integral membrane subunit MlaE

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Structure of MlaFB uncovers novel mechanisms of ABC transporter regulation. Kolich LR, et al. Elife, 2020 Jun 30. PMID 32602838, Free PMC Article
  2. Structural insights into outer membrane asymmetry maintenance in Gram-negative bacteria by MlaFEDB. Tang X, et al. Nat Struct Mol Biol, 2021 Jan. PMID 33199922
  3. Unanticipated functional diversity among the TatA-type components of the Tat protein translocase. Eimer E, et al. Sci Rep, 2018 Jan 22. PMID 29358647, Free PMC Article
  4. Escherichia coli genes that reduce the lethal effects of stress. Han X, et al. BMC Microbiol, 2010 Feb 4. PMID 20128927, Free PMC Article
  5. Defining key roles for auxiliary proteins in an ABC transporter that maintains bacterial outer membrane lipid asymmetry. Thong S, et al. Elife, 2016 Aug 16. PMID 27529189, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables phospholipid transfer activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within DNA damage response IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within intermembrane phospholipid transfer IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in phospholipid transport NAS
Non-traceable Author Statement
more info
 PubMed 
acts_upstream_of_or_within response to antibiotic IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane NAS
Non-traceable Author Statement
more info
 PubMed 
part_of phospholipid-translocating ATPase complex IPI
Inferred from Physical Interaction
more info
 PubMed 

General protein information

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Preferred Names
intermembrane phospholipid transport system protein MlaB

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    3336963..3337256 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_417658.4 intermembrane phospholipid transport system protein MlaB [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_417658.4

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A5B9ATC2
    Conserved Domains (1) summary
    NF033618
    Location:3 → 96
    mlaB_1; lipid asymmetry maintenance protein MlaB
Nucleotide Protein
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