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envR DNA-binding transcriptional repressor EnvR [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 947704, updated on 17-Dec-2024

Summary

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Official Symbol
envR
Official Full Name
DNA-binding transcriptional repressor EnvR
Primary source
ECOCYC:EG11741
Locus tag
b3264
See related
ASAP:ABE-0010712
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
acrS; ECK3251; yhdK
Summary
TetR family. [More information is available at EcoGene: EG11741]. EnvR , also known as AcrS, represses the transcription of genes encoding a drug efflux pump that has a role in resistance to antibiotics . [More information is available at EcoCyc: EG11741].
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Genomic context

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Sequence:
NC_000913.3 (3412803..3413465, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene DNA adenine methyltransferase Neighboring gene DUF2556 domain-containing protein YhdU Neighboring gene multidrug efflux pump membrane fusion lipoprotein AcrE Neighboring gene multidrug efflux pump RND permease AcrF

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Regulation of jadomycin B production in Streptomyces venezuelae ISP5230: involvement of a repressor gene, jadR2. Yang K, et al. J Bacteriol, 1995 Nov. PMID 7592375, Free PMC Article
  2. Regulation of the permeability of the gonococcal cell envelope by the mtr system. Pan W, et al. Mol Microbiol, 1994 Feb. PMID 8196548
  3. Overexpression of the multidrug efflux operon acrEF by insertional activation with IS1 or IS10 elements in Salmonella enterica serovar typhimurium DT204 acrB mutants selected with fluoroquinolones. Olliver A, et al. Antimicrob Agents Chemother, 2005 Jan. PMID 15616308, Free PMC Article
  4. Multidrug resistance pumps in bacteria: variations on a theme. Lewis K. Trends Biochem Sci, 1994 Mar. PMID 8203018
  5. Molecular analysis and nucleotide sequence of the envCD operon of Escherichia coli. Klein JR, et al. Mol Gen Genet, 1991 Nov. PMID 1720861

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. AcrS represses the gene expression of multidrug efflux genes, acrA and acrB
    Title: AcrS/EnvR represses expression of the acrAB multidrug efflux genes in Escherichia coli.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within negative regulation of DNA-templated transcription IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within response to xenobiotic stimulus IMP
Inferred from Mutant Phenotype
more info
 PubMed 

General protein information

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Preferred Names
DNA-binding transcriptional repressor EnvR

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    3412803..3413465 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_417730.1 DNA-binding transcriptional repressor EnvR [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_417730.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A5B9APK8
    Conserved Domains (1) summary
    PRK09975
    Location:1 → 213
    PRK09975; DNA-binding transcriptional regulator EnvR; Provisional
Nucleotide Protein
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