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pgaD poly-N-acetyl-D-glucosamine synthase subunit PgaD [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 947503, updated on 3-Dec-2024

Summary

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Official Symbol
pgaD
Official Full Name
poly-N-acetyl-D-glucosamine synthase subunit PgaD
Primary source
ECOCYC:G6528
Locus tag
b1021
See related
ASAP:ABE-0003460
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK1011; hmsS; ycdP
Summary
PgaD complements a mutation in the homologous Y. pestis hemin storage gene hmsS. [More information is available at EcoGene: EG13862]. The PgaD protein is involved in biofilm formation. [More information is available at EcoCyc: G6528].
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Genomic context

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Sequence:
NC_000913.3 (1086106..1086519, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene heme-containing peroxidase/deferrochelatase Neighboring gene ATP-binding protein PhoH Neighboring gene poly-N-acetyl-D-glucosamine synthase subunit PgaC Neighboring gene poly-beta-1,6-N-acetyl-D-glucosamine N-deacetylase and beta-1,6 glycoside hydrolase Neighboring gene partially deacetylated poly-beta-1,6-N-acetyl-D-glucosamine export outer membrane porin

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Allosteric activation of exopolysaccharide synthesis through cyclic di-GMP-stimulated protein-protein interaction. Steiner S, et al. EMBO J, 2013 Feb 6. PMID 23202856, Free PMC Article
  2. Depolymerization of beta-1,6-N-acetyl-D-glucosamine disrupts the integrity of diverse bacterial biofilms. Itoh Y, et al. J Bacteriol, 2005 Jan. PMID 15601723, Free PMC Article
  3. HmsT, a protein essential for expression of the haemin storage (Hms+) phenotype of Yersinia pestis. Jones HA, et al. Microbiology (Reading), 1999 Aug. PMID 10463178
  4. Effect of growth conditions on poly-N-acetylglucosamine expression and biofilm formation in Escherichia coli. Cerca N, et al. FEMS Microbiol Lett, 2008 Jun. PMID 18445167
  5. Spatial periodicity of Escherichia coli K-12 biofilm microstructure initiates during a reversible, polar attachment phase of development and requires the polysaccharide adhesin PGA. Agladze K, et al. J Bacteriol, 2005 Dec. PMID 16321928, Free PMC Article

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within cell adhesion involved in biofilm formation EXP
Inferred from Experiment
more info
 PubMed 
involved_in cell adhesion involved in biofilm formation IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within cell adhesion involved in biofilm formation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cell adhesion involved in single-species biofilm formation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane RCA
inferred from Reviewed Computational Analysis
more info
 PubMed 

General protein information

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Preferred Names
poly-N-acetyl-D-glucosamine synthase subunit PgaD

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    1086106..1086519 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_415540.1 poly-N-acetyl-D-glucosamine synthase subunit PgaD [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_415540.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A792HNV3
    Conserved Domains (1) summary
    PRK14585
    Location:1 → 137
    pgaD; putative PGA biosynthesis protein; Provisional
Nucleotide Protein
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