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hycH formate hydrogenlyase assembly protein [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 947438, updated on 17-Dec-2024

Summary

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Official Symbol
hycH
Official Full Name
formate hydrogenlyase assembly protein
Primary source
ECOCYC:EG10481
Locus tag
b2718
See related
ASAP:ABE-0008933
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK2713; hevH
Summary
FhlA regulon. [More information is available at EcoGene: EG10481]. The HycH protein does not appear to be part of the functional formate hydrogenlyase complex, but is required for maturation of hydrogenase 3 . [More information is available at EcoCyc: EG10481].
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Genomic context

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Sequence:
NC_000913.3 (2843036..2843446, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene beta-glucoside specific PTS enzyme IIBC component Neighboring gene 6-phospho-beta-glucosidase AscB Neighboring gene hydrogenase 3 maturation protease Neighboring gene formate hydrogenlyase subunit HycG Neighboring gene formate hydrogenlyase subunit HycF Neighboring gene formate hydrogenlyase subunit HycE

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Regulated expression in vitro of genes coding for formate hydrogenlyase components of Escherichia coli. Hopper S, et al. J Biol Chem, 1994 Jul 29. PMID 8034728
  2. Nucleotide sequence and expression of an operon in Escherichia coli coding for formate hydrogenlyase components. Böhm R, et al. Mol Microbiol, 1990 Feb. PMID 2187144
  3. The dual-function chaperone HycH improves assembly of the formate hydrogenlyase complex. Lindenstrauß U, et al. Biochem J, 2017 Aug 11. PMID 28718449
  4. Mutational analysis of the operon (hyc) determining hydrogenase 3 formation in Escherichia coli. Sauter M, et al. Mol Microbiol, 1992 Jun. PMID 1625581
  5. Characterisation of a protease from Escherichia coli involved in hydrogenase maturation. Rossmann R, et al. Eur J Biochem, 1995 Jan 15. PMID 7851435

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The data presented here show that HycH has a novel dual role as an assembly chaperone for a cytoplasmic [NiFe]-hydrogenase.
    Title: The dual-function chaperone HycH improves assembly of the formate hydrogenlyase complex.
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by EcoCyc

Process Evidence Code Pubs
acts_upstream_of_or_within protein-containing complex assembly IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
formate hydrogenlyase assembly protein

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    2843036..2843446 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_417198.1 formate hydrogenlyase assembly protein [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_417198.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A376MGP2
    Conserved Domains (1) summary
    PRK15084
    Location:1 → 134
    PRK15084; formate hydrogenlyase maturation protein HycH; Provisional
Nucleotide Protein
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