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csrA carbon storage regulator [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 947176, updated on 3-Dec-2024

Summary

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Official Symbol
csrA
Official Full Name
carbon storage regulator
Primary source
ECOCYC:EG11447
Locus tag
b2696
See related
ASAP:ABE-0008866
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK2691; zfiA
Summary
CsrA translationally represses the GGDEF diguanylate cyclase enzymes YdeH and YcdT, which are needed for normal motility (Jonas, 2008). [More information is available at EcoGene: EG11447]. CsrA is a regulator of carbohydrate metabolism that affects glycogen biosynthesis , glycogen degradation , gluconeogenesis , and glycolysis . [More information is available at EcoCyc: EG11447].
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Genomic context

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Sequence:
NC_000913.3 (2818961..2819146, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene tRNA-Arg Neighboring gene tRNA-Ser Neighboring gene alanine--tRNA ligase/DNA-binding transcriptional repressor Neighboring gene RecA inhibitor RecX

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Conditional essentiality of the csrA gene in Escherichia coli. Timmermans J, et al. J Bacteriol, 2009 Mar. PMID 19103924, Free PMC Article
  2. A novel endogenous induction of ColE7 expression in a csrA mutant of Escherichia coli. Chang HW, et al. Curr Microbiol, 2013 Apr. PMID 23247769
  3. Posttranscriptional repression of the cel gene of the ColE7 operon by the RNA-binding protein CsrA of Escherichia coli. Yang TY, et al. Nucleic Acids Res, 2010 Jul. PMID 20378712, Free PMC Article
  4. Regulation of Salmonella enterica serovar typhimurium invasion genes by csrA. Altier C, et al. Infect Immun, 2000 Dec. PMID 11083797, Free PMC Article
  5. Thymineless death is inhibited by CsrA in Escherichia coli lacking the SOS response. Hamilton HM, et al. DNA Repair (Amst), 2013 Nov. PMID 24075571, Free PMC Article

See all (75) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Two Polyketides Intertwined in Complex Regulation: Posttranscriptional CsrA-Mediated Control of Colibactin and Yersiniabactin Synthesis in Escherichia coli.
    Title: Two Polyketides Intertwined in Complex Regulation: Posttranscriptional CsrA-Mediated Control of Colibactin and Yersiniabactin Synthesis in Escherichia coli.
  2. CsrA-Mediated Translational Activation of ymdA Expression in Escherichia coli.
    Title: CsrA-Mediated Translational Activation of ymdA Expression in Escherichia coli.
  3. CsrA was found to regulate cellular iron levels and support growth by repressing the expression of FtnB and Bfr.
    Title: Regulation of Iron Storage by CsrA Supports Exponential Growth of Escherichia coli.
  4. findings expand the scope of pathways affected by the csrA regulon and emphasize its importance as a global regulator.
    Title: Metabolome and transcriptome-wide effects of the carbon storage regulator A in enteropathogenic Escherichia coli.
  5. Based on expression studies with site-directed mutants, an OFF-ON-OFF toggle model is proposed that results in transient translation of SepL and EspA filament assembly. Under this model, the nascent mRNA is translationally off, before being activated by CsrA, and then repressed by Hfq and Spot42.
    Title: An RNA-dependent mechanism for transient expression of bacterial translocation filaments.
  6. The authors propose that in both Azotobacter vinelandii and Escherichia coli, RppH activity plays a role in the expression of the translational regulator protein RsmA/CsrA.
    Title: The pyrophosphohydrolase RppH is involved in the control of RsmA/CsrA expression in Azotobacter vinelandii and Escherichia coli.
  7. Findings indicate the integration of CsrA throughout the regulatory network, where it orchestrates vast effects on gene expression.
    Title: Global role of the bacterial post-transcriptional regulator CsrA revealed by integrated transcriptomics.
  8. findings show that CsrA employs a novel regulatory mechanism to repress translation of iraD; CsrA binds to four sites in the iraD leader transcript but does not directly occlude ribosome binding to the iraD SD sequence; instead, CsrA represses translation of a short open reading frame encoded upstream of iraD, causing repression of iraD translation
    Title: Translational Repression of the RpoS Antiadapter IraD by CsrA Is Mediated via Translational Coupling to a Short Upstream Open Reading Frame.
  9. Study provides evidence that CsrA is a global positive regulator of mRNA stability in Escherichia coli and suggests that this mechanism might contribute to metabolic adaptation by regulating expression of genes involved in carbon metabolism and transport independently of transcriptional regulation.
    Title: The Csr system regulates genome-wide mRNA stability and transcription and thus gene expression in Escherichia coli.
  10. Data show that CsrA binds directly to the 5' end of the transcript encoding AcrAB.
    Title: CsrA maximizes expression of the AcrAB multidrug resistance transporter.
Submit: New GeneRIF Correction See all GeneRIFs (33)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables mRNA 5'-UTR binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in mRNA catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in mRNA stabilization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of translation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of translational initiation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within positive regulation of translational initiation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of translational initiation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within positive regulation of translational initiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of carbohydrate metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of translation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
carbon storage regulator

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    2818961..2819146 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_417176.1 carbon storage regulator [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_417176.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A485JE11
    Conserved Domains (1) summary
    PRK01712
    Location:1 → 60
    PRK01712; carbon storage regulator CsrA
Nucleotide Protein
Heading Accession and Version

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