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recX RecA inhibitor RecX [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 947172, updated on 17-Dec-2024

Summary

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Official Symbol
recX
Official Full Name
RecA inhibitor RecX
Primary source
ECOCYC:EG12080
Locus tag
b2698
See related
ASAP:ABE-0008872
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK2693; oraA
Summary
RecX (negative) directly competes with DinI (positive) as modulators of RecA function. lexA regulon. [More information is available at EcoGene: EG12080]. RecX associates with RecA and inhibits RecA ATP hydrolysis, coprotease, and DNA strand exchange activities . [More information is available at EcoCyc: EG12080].
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Genomic context

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Sequence:
NC_000913.3 (2822139..2822639, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene carbon storage regulator Neighboring gene alanine--tRNA ligase/DNA-binding transcriptional repressor Neighboring gene DNA recombination/repair protein RecA Neighboring gene NMN aminohydrolase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Nucleotide sequence between recA and alaSp in E. coli K12 and the sequence change in four recA mutations. Zaitsev E, et al. Mutat Res, 1994 Apr. PMID 7512687
  2. Tryptophanase in sRNA control of the Escherichia coli cell cycle. Chattoraj DK. Mol Microbiol, 2007 Jan. PMID 17163965
  3. Differential cross-complementation patterns of Escherichia coli and Neisseria gonorrhoeae RecA proteins. Stohl EA, et al. Microbiology (Reading), 2002 Jun. PMID 12055302
  4. Escherichia coli RecX inhibits RecA recombinase and coprotease activities in vitro and in vivo. Stohl EA, et al. J Biol Chem, 2003 Jan 24. PMID 12427742
  5. DinI and RecX modulate RecA-DNA structures in Escherichia coli K-12. Renzette N, et al. Mol Microbiol, 2007 Jan. PMID 17163974

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The combination of RecX and UvrD are required for suppression of constitutive SOS expression by RecA.
    Title: Suppression of constitutive SOS expression by recA4162 (I298V) and recA4164 (L126V) requires UvrD and RecX in Escherichia coli K-12.
  2. there is a C-terminal point mutation in RecA protein (E343K) that significantly alters the interaction between RecA and RecX proteins
    Title: Inhibition of RecA protein by the Escherichia coli RecX protein: modulation by the RecA C terminus and filament functional state.
  3. DinI and RecX are competing modulators of RecA function
    Title: The DinI and RecX proteins are competing modulators of RecA function.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables enzyme binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within DNA damage response IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in DNA repair IEA
Inferred from Electronic Annotation
more info
  
involved_in SOS response IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within SOS response IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in regulation of DNA repair IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
RecA inhibitor RecX

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    2822139..2822639 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_417178.1 RecA inhibitor RecX [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_417178.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A8S7EGA1
    Conserved Domains (1) summary
    PRK00117
    Location:3 → 166
    recX; recombination regulator RecX; Reviewed
Nucleotide Protein
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