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selU tRNA 2-selenouridine synthase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 947063, updated on 3-Dec-2024

Summary

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Official Symbol
selU
Official Full Name
tRNA 2-selenouridine synthase
Primary source
ECOCYC:EG11768
Locus tag
b0503
See related
ASAP:ABE-0001740
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK0496; mnmH; ybbB
Summary
SelU(YbbB) has a rhodanese domain. [More information is available at EcoGene: EG11768]. The ybbB gene encodes the tRNA 2-selenouridine synthase responsible for formation of the special selenium-containing wobble base of the three tRNAs tRNALys, tRNAGlu, and tRNAGln . [More information is available at EcoCyc: EG11768].
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Genomic context

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Sequence:
NC_000913.3 (530132..531226, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene putative DNA-binding transcriptional regulator YlbG Neighboring gene DNA-binding transcriptional activator AllS Neighboring gene ureidoglycolate lyase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Escherichia coli tRNA 2-selenouridine synthase SelU selects its prenyl substrate to accomplish its enzymatic function. Szczupak P, et al. Bioorg Chem, 2022 May. PMID 35306417
  2. Escherichia coli tRNA 2-selenouridine synthase (SelU) converts S2U-RNA to Se2U-RNA via S-geranylated-intermediate. Sierant M, et al. FEBS Lett, 2018 Jul. PMID 29862510
  3. Discovery and biological characterization of geranylated RNA in bacteria. Dumelin CE, et al. Nat Chem Biol, 2012 Nov. PMID 22983156, Free PMC Article
  4. Functional diversity of the rhodanese homology domain: the Escherichia coli ybbB gene encodes a selenophosphate-dependent tRNA 2-selenouridine synthase. Wolfe MD, et al. J Biol Chem, 2004 Jan 16. PMID 14594807
  5. A purified selenophosphate-dependent enzyme from Salmonella typhimurium catalyzes the replacement of sulfur in 2-thiouridine residues in tRNAs with selenium. Veres Z, et al. Proc Natl Acad Sci U S A, 1994 Aug 16. PMID 7520175, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables tRNA 2-selenouridine synthase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables tRNA 2-selenouridine synthase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables tRNA 2-selenouridine synthase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity, transferring alkyl or aryl (other than methyl) groups IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within tRNA seleno-modification IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in tRNA wobble uridine modification IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in tRNA wobble uridine modification IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within tRNA wobble uridine modification IMP
Inferred from Mutant Phenotype
more info
 PubMed 

General protein information

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Preferred Names
tRNA 2-selenouridine synthase
NP_415036.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    530132..531226 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_415036.1 tRNA 2-selenouridine synthase [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_415036.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A2X1MYF5, A0AAI9MEZ8
    Conserved Domains (1) summary
    PRK11784
    Location:3 → 364
    PRK11784; tRNA 2-selenouridine synthase; Provisional
Nucleotide Protein
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