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pabC aminodeoxychorismate lyase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 946647, updated on 17-Dec-2024

Summary

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Official Symbol
pabC
Official Full Name
aminodeoxychorismate lyase
Primary source
ECOCYC:EG11493
Locus tag
b1096
See related
ASAP:ABE-0003709
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK1082
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Genomic context

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Sequence:
NC_000913.3 (1153300..1154109)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene acyl carrier protein Neighboring gene 3-oxoacyl-[acyl carrier protein] synthase 2 Neighboring gene endolytic murein transglycosylase Neighboring gene Tmk Neighboring gene DNA polymerase III subunit delta'

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Detection of covalent intermediates formed in the reaction of 4-amino-4-deoxychorismate synthase. Bulloch EM, et al. Chembiochem, 2005 May. PMID 15770625
  2. Stereochemistry of the transamination reaction catalyzed by aminodeoxychorismate lyase from Escherichia coli: close relationship between fold type and stereochemistry. Jhee KH, et al. J Biochem, 2000 Oct. PMID 11011151
  3. p-Aminobenzoate biosynthesis in Escherichia coli. Purification of aminodeoxychorismate lyase and cloning of pabC. Green JM, et al. J Biol Chem, 1991 Jul 15. PMID 2071583
  4. p-Aminobenzoate synthesis in Escherichia coli: purification and characterization of PabB as aminodeoxychorismate synthase and enzyme X as aminodeoxychorismate lyase. Ye QZ, et al. Proc Natl Acad Sci U S A, 1990 Dec. PMID 2251281, Free PMC Article
  5. Characterization and sequence of Escherichia coli pabC, the gene encoding aminodeoxychorismate lyase, a pyridoxal phosphate-containing enzyme. Green JM, et al. J Bacteriol, 1992 Aug. PMID 1644759, Free PMC Article

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. N-terminus verified by Edman degradation on complete protein
    Title: p-Aminobenzoate biosynthesis in Escherichia coli. Purification of aminodeoxychorismate lyase and cloning of pabC.
  2. covalent intermediates formed during the enzyme reaction
    Title: Detection of covalent intermediates formed in the reaction of 4-amino-4-deoxychorismate synthase.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables 4-amino-4-deoxychorismate lyase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 4-amino-4-deoxychorismate lyase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables 4-amino-4-deoxychorismate lyase activity IEA
Inferred from Electronic Annotation
more info
  
enables lyase activity IEA
Inferred from Electronic Annotation
more info
  
enables pyridoxal phosphate binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables pyridoxal phosphate binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in carboxylic acid biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in folic acid biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in para-aminobenzoic acid biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within para-aminobenzoic acid biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in tetrahydrofolate biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
aminodeoxychorismate lyase
NP_415614.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    1153300..1154109
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_415614.1 aminodeoxychorismate lyase [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_415614.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A2X1IXM2
    Conserved Domains (1) summary
    PRK06092
    Location:1 → 268
    PRK06092; 4-amino-4-deoxychorismate lyase; Reviewed
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

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