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galF UTP:glucose-1-phosphate uridylyltransferase, low activity [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 946560, updated on 3-Dec-2024

Summary

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Official Symbol
galF
Official Full Name
UTP:glucose-1-phosphate uridylyltransferase, low activity
Primary source
ECOCYC:G7093
Locus tag
b2042
See related
ASAP:ABE-0006771
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK2036; wcaN; yefG
Summary
Not required for colanic acid synthesis. [More information is available at EcoGene: EG13578]. GalF stabilizes and may be complexed with the |FRAME: [More information is available at EcoCyc: G7093].
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Genomic context

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Sequence:
NC_000913.3 (2113434..2114327, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene dTDP-4-dehydrorhamnose 3,5-epimerase Neighboring gene glucose-1-phosphate thymidylyltransferase 1 Neighboring gene dTDP-4-dehydrorhamnose reductase Neighboring gene dTDP-glucose 4,6-dehydratase 1 Neighboring gene putative colanic acid biosynthesis protein WcaM Neighboring gene putative colanic acid biosynthesis glycosyl transferase WcaL Neighboring gene colanic acid biosynthesis pyruvyl transferase WcaK

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. On the Ancestral UDP-Glucose Pyrophosphorylase Activity of GalF from Escherichia coli. Ebrecht AC, et al. Front Microbiol, 2015. PMID 26617591, Free PMC Article
  2. Biosynthesis and assembly of capsular polysaccharides in Escherichia coli. Whitfield C. Annu Rev Biochem, 2006. PMID 16756484
  3. CONTROL ASPECTS OF URIDINE 5'-DIPHOSPHATE GLUCOSE AND THYMIDINE 5'-DIPHOSPHATE GLUCOSE SYNTHESIS BY MICROBIAL ENZYMES. BERNSTEIN RL, et al. J Biol Chem, 1965 Jan. PMID 14253441
  4. UTP: alpha-D-glucose-1-phosphate uridylyltransferase of Escherichia coli: isolation and DNA sequence of the galU gene and purification of the enzyme. Weissborn AC, et al. J Bacteriol, 1994 May. PMID 8169209, Free PMC Article
  5. The GalF protein of Escherichia coli is not a UDP-glucose pyrophosphorylase but interacts with the GalU protein possibly to regulate cellular levels of UDP-glucose. Marolda CL, et al. Mol Microbiol, 1996 Dec. PMID 8971705

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables UTP:glucose-1-phosphate uridylyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables UTP:glucose-1-phosphate uridylyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables enzyme regulator activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotidyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in UDP-alpha-D-glucose metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in lipopolysaccharide biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in nucleotide-sugar metabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
UTP:glucose-1-phosphate uridylyltransferase, low activity

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    2113434..2114327 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_416546.1 UTP:glucose-1-phosphate uridylyltransferase, low activity [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_416546.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A0A8J5A0
    Conserved Domains (1) summary
    PRK10122
    Location:1 → 297
    PRK10122; UTP--glucose-1-phosphate uridylyltransferase GalF
Nucleotide Protein
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