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rcsA DNA-binding transcriptional activator RcsA [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 946467, updated on 3-Dec-2024

Summary

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Official Symbol
rcsA
Official Full Name
DNA-binding transcriptional activator RcsA
Primary source
ECOCYC:EG10820
Locus tag
b1951
See related
ASAP:ABE-0006482
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
cpsR; ECK1949
Summary
The binding site length comes from a single reference . [More information is available at EcoCyc: EG10820].
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Genomic context

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Sequence:
NC_000913.3 (2023968..2024591)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene flagellar biosynthesis protein FliQ Neighboring gene flagellar biosynthesis protein FliR Neighboring gene protein DsrB Neighboring gene stress-induced protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The role of RcsA in the adaptation and survival of Escherichia coli K92. Navasa N, et al. FEMS Microbiol Lett, 2019 Apr 1. PMID 31089698
  2. Expression of Vi antigen in Escherichia coli K-12: characterization of ViaB from Citrobacter freundii and identity of ViaA with RcsB. Houng HS, et al. J Bacteriol, 1992 Sep. PMID 1522067, Free PMC Article
  3. Acyl-homoserine lactones can induce virus production in lysogenic bacteria: an alternative paradigm for prophage induction. Ghosh D, et al. Appl Environ Microbiol, 2009 Nov. PMID 19783745, Free PMC Article
  4. RcsA, an unstable positive regulator of capsular polysaccharide synthesis. Stout V, et al. J Bacteriol, 1991 Mar. PMID 1999391, Free PMC Article
  5. Regulation of capsule synthesis includes interactions of the RcsC/RcsB regulatory pair. Stout V. Res Microbiol, 1994 Jun-Aug. PMID 7855424

See all (53) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Our results show that RcsA protects E. coli K92 against osmotic and, especially, oxidative stress at low temperatures.
    Title: The role of RcsA in the adaptation and survival of Escherichia coli K92.
  2. The authors conclude that RcsA is indeed proteolized by ClpYQ protease.
    Title: The degradation of RcsA by ClpYQ(HslUV) protease in Escherichia coli.
  3. These mutant rpoB RNA polymerases affect rcsA transcription, but per se are not defective either at rcsA or at cps promoters ande hence lead to increased capsular polysaccharide synthesis in Deltalon strains of Escherichia coli.
    Title: Suppression of capsule expression in Δlon strains of Escherichia coli by two novel rpoB mutations in concert with HNS: possible role for DNA bending at rcsA promoter.
  4. N-terminus verified by Edman degradation on mature peptide
    Title: RcsA, an unstable positive regulator of capsular polysaccharide synthesis.
  5. We showed that the poor growth at 37 degrees C was corrected by disruption of the rcsA gene, which codes for a coregulator protein that interacts with the RcsB response regulator of the phosphorelay system.
    Title: RcsA-dependent and -independent growth defects caused by the activated Rcs phosphorelay system in the Escherichia coli pgsA null mutant.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within DNA-templated transcription EXP
Inferred from Experiment
more info
 PubMed 
acts_upstream_of_or_within DNA-templated transcription IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within DNA-templated transcription IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in negative regulation of DNA-templated transcription NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in positive regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of bacterial-type flagellum-dependent cell motility NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in regulation of capsule organization IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
part_of transcription regulator complex IPI
Inferred from Physical Interaction
more info
 PubMed 

General protein information

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Preferred Names
DNA-binding transcriptional activator RcsA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    2023968..2024591
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_416461.1 DNA-binding transcriptional activator RcsA [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_416461.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A6C9JHE8
    Conserved Domains (1) summary
    PRK15411
    Location:1 → 207
    rcsA; transcriptional regulator RcsA
Nucleotide Protein
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