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nudG 5-hydroxy-CTP diphosphatase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 946277, updated on 3-Dec-2024

Summary

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Official Symbol
nudG
Official Full Name
5-hydroxy-CTP diphosphatase
Primary source
ECOCYC:G6954
Locus tag
b1759
See related
ASAP:ABE-0005855
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK1757; orf135; ynjG
Summary
Nudix hydrolase. [More information is available at EcoGene: EG14009]. NudG is a member of the Nudix hydrolase family and shows high specificity for hydrolysis of pyrimidine (deoxy)nucleoside triphosphates . [More information is available at EcoCyc: G6954].
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Genomic context

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Sequence:
NC_000913.3 (1841490..1841897)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene molybdopterin synthase sulfurtransferase Neighboring gene CDP-alcohol phosphatidyltransferase domain-containing protein YnjF Neighboring gene DUF1496 domain-containing protein YnjH Neighboring gene glutamate dehydrogenase Neighboring gene DUF1266 domain-containing protein YnjI

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Suppression of spontaneous and hydrogen peroxide-induced mutations by a MutT-type nucleotide pool sanitization enzyme, the Escherichia coli Orf135 protein. Kamiya H, et al. Genes Cells, 2003 Dec. PMID 14750949
  2. Hydrolysis of oxidized nucleotides by the Escherichia coli Orf135 protein. Kamiya H, et al. Biochem Biophys Res Commun, 2001 Nov 2. PMID 11676470
  3. Orf135 from Escherichia coli Is a Nudix hydrolase specific for CTP, dCTP, and 5-methyl-dCTP. O'Handley SF, et al. J Biol Chem, 2001 Feb 23. PMID 11053429
  4. Mutagenesis by damaged deoxyribonucleotides and its prevention by MutT-type hydrolyzing enzymes. Kamiya H, et al. Nucleic Acids Symp Ser (Oxf), 2004. PMID 17150583
  5. Insights into substrate recognition by the Escherichia coli Orf135 protein through its solution structure. Kawasaki K, et al. Biochem Biophys Res Commun, 2012 Apr 6. PMID 22414689

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables 8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 8-oxo-GDP phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 8-oxo-dGDP phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables dCTP diphosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in DNA repair IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in DNA repair IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
5-hydroxy-CTP diphosphatase
NP_416273.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    1841490..1841897
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_416273.1 5-hydroxy-CTP diphosphatase [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_416273.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0AAE9PYC1
    Conserved Domains (1) summary
    PRK10546
    Location:1 → 135
    PRK10546; pyrimidine (deoxy)nucleoside triphosphate diphosphatase
Nucleotide Protein
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