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helD DNA helicase IV [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 946227, updated on 3-Dec-2024

Summary

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Official Symbol
helD
Official Full Name
DNA helicase IV
Primary source
ECOCYC:EG10426
Locus tag
b0962
See related
ASAP:ABE-0003257
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK0953; srjB
Summary
Overexpression causes filamentous biofilm formation. [More information is available at EcoGene: EG10426]. The HelD protein, DNA helicase IV, is an ATP-dependent 3'-to-5' DNA helicase involved in the RecF pathway of recombination . [More information is available at EcoCyc: EG10426].
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Genomic context

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Sequence:
NC_000913.3 (1024471..1026525)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene transcriptional coactivator for CRP Neighboring gene putative transporter YccS Neighboring gene PF03733 family inner membrane protein YccF Neighboring gene methylglyoxal synthase Neighboring gene DUF2057 domain-containing protein YccT

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Study of the ATP-binding site of helicase IV from Escherichia coli. Dubaele S, et al. Biochem Biophys Res Commun, 2006 Mar 17. PMID 16442499
  2. Purification and characterization of a new DNA-dependent ATPase with helicase activity from Escherichia coli. Wood ER, et al. J Biol Chem, 1987 Nov 5. PMID 2822720
  3. Double helicase II (uvrD)-helicase IV (helD) deletion mutants are defective in the recombination pathways of Escherichia coli. Mendonca VM, et al. J Bacteriol, 1993 Aug. PMID 8335623, Free PMC Article
  4. Genetic analysis of delta helD and delta uvrD mutations in combination with other genes in the RecF recombination pathway in Escherichia coli: suppression of a ruvB mutation by a uvrD deletion. Mendonca VM, et al. Genetics, 1995 Oct. PMID 8647383, Free PMC Article
  5. Suppression of recJ exonuclease mutants of Escherichia coli by alterations in DNA helicases II (uvrD) and IV (helD). Lovett ST, et al. Genetics, 1995 May. PMID 7635292, Free PMC Article

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. N-terminus verified by Edman degradation on complete protein
    Title: The molecular cloning of the gene encoding the Escherichia coli 75-kDa helicase and the determination of its nucleotide sequence and gentic map position.
  2. helicase IV from Escherichia coli, utilizes a conserved glutamine and conserved aromatic residue to interact with ATP
    Title: Study of the ATP-binding site of helicase IV from Escherichia coli.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables 3'-5' DNA helicase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 3'-5' DNA helicase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables ATP-dependent H2AZ histone chaperone activity IEA
Inferred from Electronic Annotation
more info
  
enables ATP-dependent H3-H4 histone complex chaperone activity IEA
Inferred from Electronic Annotation
more info
  
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA clamp loader activity IEA
Inferred from Electronic Annotation
more info
  
enables DNA helicase activity IEA
Inferred from Electronic Annotation
more info
  
enables chromatin extrusion motor activity IEA
Inferred from Electronic Annotation
more info
  
enables cohesin loader activity IEA
Inferred from Electronic Annotation
more info
  
enables double-stranded DNA helicase activity IEA
Inferred from Electronic Annotation
more info
  
enables forked DNA-dependent helicase activity IEA
Inferred from Electronic Annotation
more info
  
enables four-way junction helicase activity IEA
Inferred from Electronic Annotation
more info
  
enables helicase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables isomerase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables single-stranded 3'-5' DNA helicase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in DNA duplex unwinding IEA
Inferred from Electronic Annotation
more info
  
involved_in chromatin looping IEA
Inferred from Electronic Annotation
more info
  
involved_in chromatin remodeling IEA
Inferred from Electronic Annotation
more info
  
involved_in recombinational repair IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
DNA helicase IV

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    1024471..1026525
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_415482.1 DNA helicase IV [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_415482.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A895P2F6
    Conserved Domains (1) summary
    PRK11054
    Location:1 → 684
    helD; DNA helicase IV; Provisional
Nucleotide Protein
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