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fadK short chain acyl-CoA synthetase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 946213, updated on 3-Dec-2024

Summary

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Official Symbol
fadK
Official Full Name
short chain acyl-CoA synthetase
Primary source
ECOCYC:EG12357
Locus tag
b1701
See related
ASAP:ABE-0005676
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK1699; ydiD
Summary
AFMB Structural Genomics target Number 54 (http://afmb.cnrs-mrs.fr/article171.html). [More information is available at EcoGene: EG12357]. FadK is an acyl-CoA synthetase that is primarily active on short chain fatty acids and acts in anaerobic -oxidation of fatty acids . [More information is available at EcoCyc: EG12357].
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Genomic context

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Sequence:
NC_000913.3 (1782977..1784677)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene putative electron transfer flavoprotein subunit YdiR Neighboring gene putative electron transfer flavoprotein-quinone oxidoreductase YdiS Neighboring gene ferredoxin-like protein YdiT Neighboring gene phosphoenolpyruvate synthetase Neighboring gene phosphoenolpyruvate synthetase regulatory protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The Escherichia coli fadK (ydiD) gene encodes an anerobically regulated short chain acyl-CoA synthetase. Morgan-Kiss RM, et al. J Biol Chem, 2004 Sep 3. PMID 15213221
  2. Transmembrane movement of exogenous long-chain fatty acids: proteins, enzymes, and vectorial esterification. Black PN, et al. Microbiol Mol Biol Rev, 2003 Sep. PMID 12966144, Free PMC Article
  3. An expanded genome-scale model of Escherichia coli K-12 (iJR904 GSM/GPR). Reed JL, et al. Genome Biol, 2003. PMID 12952533, Free PMC Article
  4. Intrinsic and extrinsic approaches for detecting genes in a bacterial genome. Borodovsky M, et al. Nucleic Acids Res, 1994 Nov 11. PMID 7984428, Free PMC Article
  5. Genome-wide screening of genes required for swarming motility in Escherichia coli K-12. Inoue T, et al. J Bacteriol, 2007 Feb. PMID 17122336, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables ligase activity, forming carbon-sulfur bonds IEA
Inferred from Electronic Annotation
more info
  
enables medium-chain fatty acid-CoA ligase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in fatty acid beta-oxidation IEA
Inferred from Electronic Annotation
more info
  
involved_in fatty acid metabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within fatty acid oxidation EXP
Inferred from Experiment
more info
 PubMed 
Component Evidence Code Pubs
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
short chain acyl-CoA synthetase
NP_416216.5

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    1782977..1784677
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_416216.5 short chain acyl-CoA synthetase [Escherichia coli str. K-12 substr. MG1655]

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A5P0J300
    Conserved Domains (1) summary
    PRK06087
    Location:20 → 566
    PRK06087; medium-chain fatty-acid--CoA ligase
Nucleotide Protein
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Gene LinkOut

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