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nemA N-ethylmaleimide reductase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 946164, updated on 3-Dec-2024

Summary

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Official Symbol
nemA
Official Full Name
N-ethylmaleimide reductase
Primary source
ECOCYC:G6890
Locus tag
b1650
See related
ASAP:ABE-0005516
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK1646; ydhN
Summary
NemA catalyzes the reduction of N-ethylmaleimide to N-ethylsuccinimide . [More information is available at EcoCyc: G6890].
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Genomic context

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Sequence:
NC_000913.3 (1726659..1727756)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene DUF1289 domain-containing protein YdhL Neighboring gene DNA-binding transcriptional repressor NemR Neighboring gene lactoylglutathione lyase Neighboring gene ribonuclease T

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Studies on the metabolism of unsaturated fatty acids. II. Separation and general properties of reduced nicotinamide adenine dinucleotide phosphate dependent cis-2-enoyl-coenzyme A reductase from Escherichia coli K-12. Mizugaki M, et al. Chem Pharm Bull (Tokyo), 1979 Oct. PMID 43196
  2. Studies on the the metabolism of unsaturated fatty acids. VI. Stereochemical studies of the reaction catalyzed by cis-2-enoyl-coenzyme A reductase of escherichia coli. Mizugaki M, et al. Chem Pharm Bull (Tokyo), 1982 Jun. PMID 6751582
  3. Studies on the metabolism of unsaturated fatty acids. IV. N-Ethylmaleimide reducing activity in Escherichia coli K-12. Mizugaki M, et al. Chem Pharm Bull (Tokyo), 1981 Feb. PMID 7023711
  4. The effects of unsaturated fatty acids, oxidizing agents and Michael reaction acceptors on the induction of N-ethylmaleimide reductase in Escherichia coli: possible application for drug design of chemoprotectors. Miura K, et al. Methods Find Exp Clin Pharmacol, 1997 Apr. PMID 9203161
  5. Study of the role played by NfsA, NfsB nitroreductase and NemA flavin reductase from Escherichia coli in the conversion of ethyl 2-(2'-nitrophenoxy)acetate to 4-hydroxy-(2H)-1,4-benzoxazin-3(4H)-one (D-DIBOA), a benzohydroxamic acid with interesting biological properties. Valle A, et al. Appl Microbiol Biotechnol, 2012 Apr. PMID 22173483

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. We propose that cells have a cytosolic system consisting of the nemRA-gloA operon for the reduction of electrophiles, especially quinones and glyoxals, to maintain an appropriate intracellular redox balance.
    Title: Novel regulatory system nemRA-gloA for electrophile reduction in Escherichia coli K-12.
  2. NfsA and NfsB, but not NemA, are responsible for the conversion of ethyl 2-(2'-nitrophenoxy)acetate.
    Title: Study of the role played by NfsA, NfsB nitroreductase and NemA flavin reductase from Escherichia coli in the conversion of ethyl 2-(2'-nitrophenoxy)acetate to 4-hydroxy-(2H)-1,4-benzoxazin-3(4H)-one (D-DIBOA), a benzohydroxamic acid with interesting biological properties.
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables FMN binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables FMN binding IEA
Inferred from Electronic Annotation
more info
  
enables N-ethylmaleimide reductase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables N-ethylmaleimide reductase activity IEA
Inferred from Electronic Annotation
more info
  
enables chromate reductase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity, acting on other nitrogenous compounds as donors, with NAD or NADP as acceptor IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within 2,4,6-trinitrotoluene catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within nitroglycerin metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within xenobiotic metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
N-ethylmaleimide reductase

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    1726659..1727756
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_416167.1 N-ethylmaleimide reductase [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_416167.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A9P2I9R5
    Conserved Domains (1) summary
    PRK10605
    Location:4 → 365
    PRK10605; N-ethylmaleimide reductase; Provisional
Nucleotide Protein
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