U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

maeA malate dehydrogenase (oxaloacetate-decarboxylating) [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 946031, updated on 3-Dec-2024

Summary

Go to the top of the page Help
Official Symbol
maeA
Official Full Name
malate dehydrogenase (oxaloacetate-decarboxylating)
Primary source
ECOCYC:EG10948
Locus tag
b1479
See related
ASAP:ABE-0004931
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK1473; sfcA
Summary
MaeA catalyzes four reactions: [More information is available at EcoGene: EG10948]. Escherichia coli K-12 encodes two "malic enzymes" which catalyze the decarboxylation of malate to form pyruvate. [More information is available at EcoCyc: EG10948].
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Sequence:
NC_000913.3 (1553972..1555669, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene DNA-binding transcriptional regulator YddM Neighboring gene ethanol dehydrogenase/alcohol dehydrogenase Neighboring gene ribosome-associated protein Sra Neighboring gene biofilm-dependent modulation protein

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Essential sulfhydryl group of malic enzyme from Escherichia coli. Chang GG, et al. J Protein Chem, 1993 Feb. PMID 8427636
  2. Role of metal cofactors in enzyme regulation. Differences in the regulatory properties of the Escherichia coli nicotinamide adenine dinucleotide specific malic enzyme depending on whether Mg2+ or Mn2+ serves as divalent cation. Milne JA, et al. Biochemistry, 1979 Aug 7. PMID 224913
  3. Effect of photooxidation on catalytic and regulatory properties of NAD-linked malic enzyme from Escherichia coli. Saito R, et al. Physiol Chem Phys Med NMR, 1985. PMID 3898156
  4. Studies on regulatory functions of malic enzymes. II. Purification and molecular properties of nicotinamide adenine dinucleotide-linked malic enzyme from Eschericha coli. Yamaguchi M, et al. J Biochem, 1973 Jan. PMID 4144085
  5. Alteration of NAD-linked malic enzyme-catalyzed reactions by sulfhydryl group modification. Yamaguchi M, et al. Biochem Biophys Res Commun, 1973 Dec 19. PMID 4358933

See all (32) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables NAD binding IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables malate dehydrogenase (decarboxylating) (NAD+) activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables malate dehydrogenase (decarboxylating) (NAD+) activity IEA
Inferred from Electronic Annotation
more info
  
enables malic enzyme activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables oxaloacetate decarboxylase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within gluconeogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in malate metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in pyruvate metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
malate dehydrogenase (oxaloacetate-decarboxylating)
NP_415996.2

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    1553972..1555669 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_415996.2 malate dehydrogenase (oxaloacetate-decarboxylating) [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_415996.2

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A377CW06
    Conserved Domains (1) summary
    PRK13529
    Location:1 → 563
    PRK13529; oxaloacetate-decarboxylating malate dehydrogenase
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.