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paaX DNA-binding transcriptional repressor PaaX [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 945966, updated on 17-Dec-2024

Summary

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Official Symbol
paaX
Official Full Name
DNA-binding transcriptional repressor PaaX
Primary source
ECOCYC:G6720
Locus tag
b1399
See related
ASAP:ABE-0004674
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK1396; ydbY
Summary
The "phenylacetic acid" regulator , PaaX, is a transcriptional repressor that participates in controlling transcriptional regulation of genes involved in the catabolism of an aromatic compound, phenylacetic acid (PA) . [More information is available at EcoCyc: G6720].
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Genomic context

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Sequence:
NC_000913.3 (1463539..1464489)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene phenylacetyl-CoA thioesterase Neighboring gene beta-ketoadipyl-CoA thiolase Neighboring gene phenylacetate-CoA ligase Neighboring gene 2-hydroxycyclohepta-1,4,6-triene-1-carboxyl-CoA thioesterase Neighboring gene uncharacterized protein YnbG Neighboring gene pseudo Neighboring gene IS2 insertion element protein InsB Neighboring gene IS2 insertion element repressor InsA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Coregulation by phenylacetyl-coenzyme A-responsive PaaX integrates control of the upper and lower pathways for catabolism of styrene by Pseudomonas sp. strain Y2. del Peso-Santos T, et al. J Bacteriol, 2006 Jul. PMID 16788190, Free PMC Article
  2. Regulation of penicillin G acylase gene expression in Escherichia coli by repressor PaaX and the cAMP-cAMP receptor protein complex. Kim HS, et al. J Biol Chem, 2004 Aug 6. PMID 15159386
  3. The hydH/G Genes from Escherichia coli code for a zinc and lead responsive two-component regulatory system. Leonhartsberger S, et al. J Mol Biol, 2001 Mar 16. PMID 11243806
  4. Functional genomics by NMR spectroscopy. Phenylacetate catabolism in Escherichia coli. Ismail W, et al. Eur J Biochem, 2003 Jul. PMID 12846838
  5. Identification of mutator genes and mutational pathways in Escherichia coli using a multicopy cloning approach. Yang H, et al. Mol Microbiol, 2004 Jul. PMID 15225322

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transcription cis-regulatory region binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within DNA-templated transcription EXP
Inferred from Experiment
more info
 PubMed 
involved_in DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within DNA-templated transcription IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within negative regulation of DNA-templated transcription initiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in phenylacetate catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in phenylacetate catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 

General protein information

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Preferred Names
DNA-binding transcriptional repressor PaaX

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    1463539..1464489
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_415917.1 DNA-binding transcriptional repressor PaaX [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_415917.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A6N6WSP4
    Conserved Domains (1) summary
    TIGR02277
    Location:21 → 303
    PaaX_trns_reg; phenylacetic acid degradation operon negative regulatory protein PaaX
Nucleotide Protein
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