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lolB outer membrane lipoprotein LolB [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 945775, updated on 17-Dec-2024

Summary

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Official Symbol
lolB
Official Full Name
outer membrane lipoprotein LolB
Primary source
ECOCYC:EG11293
Locus tag
b1209
See related
ASAP:ABE-0004059
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK1197; hemM; ychC
Summary
First 21 aa are a type II signal peptide. [More information is available at EcoGene: EG11293]. LolB is an outer membrane lipoprotein which is generally required for LolA-dependent localization of lipoproteins (including LolB itself) to the outer membrane . [More information is available at EcoCyc: EG11293].
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Genomic context

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Sequence:
NC_000913.3 (1262877..1263500, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene ribose-phosphate diphosphokinase Neighboring gene 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase Neighboring gene glutamyl-tRNA reductase Neighboring gene peptide chain release factor RF1 Neighboring gene protein-(glutamine-N(5)) methyltransferase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Ketotic hypoglycaemia. Murphy A, et al. Ir Med J, 1975 Dec 27. PMID 1052496
  2. Backbone resonance assignment for the outer membrane lipoprotein receptor LolB from Escherichia coli. Nakada S, et al. Biomol NMR Assign, 2007 Jul. PMID 19636844
  3. Deletion of lolB, encoding an outer membrane lipoprotein, is lethal for Escherichia coli and causes accumulation of lipoprotein localization intermediates in the periplasm. Tanaka K, et al. J Bacteriol, 2001 Nov. PMID 11673422, Free PMC Article
  4. Crystallization and preliminary crystallographic study of the outer-membrane lipoprotein receptor LolB, a member of the lipoprotein localization factors. Takeda K, et al. Acta Crystallogr D Biol Crystallogr, 2003 Jul. PMID 12832767
  5. Targeted mutagenesis of five conserved tryptophan residues of LolB involved in membrane localization of Escherichia coli lipoproteins. Wada R, et al. Biochem Biophys Res Commun, 2004 Oct 22. PMID 15381108

See all (35) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. kinetic parameters of lipoprotein transfer from LolA to LolB were determined
    Title: Real time analysis of lipoprotein transfer from LolA to LolB by means of surface plasmon resonance.
  2. lipoprotein binding, membrane targeting and membrane incorporation of lipoproteins are intrinsic functions of LolB.
    Title: Dissection of LolB function--lipoprotein binding, membrane targeting and incorporation of lipoproteins into lipid bilayers.
  3. With the 13C cent, 13Ca, and 13Cb chemical shifts data, the Chemical-Shift Index (CSI) method suggested that the secondary structure of LolB in solution essentially corresponded to that in the crystal structure.
    Title: Backbone resonance assignment for the outer membrane lipoprotein receptor LolB from Escherichia coli.
  4. interaction sites of LolA, LolB, and LolC which transfer lipoproteins
    Title: Model of mouth-to-mouth transfer of bacterial lipoproteins through inner membrane LolC, periplasmic LolA, and outer membrane LolB.
  5. the LolB-dependent incorporation of Pal was not affected by excess-free LolA, indicating that LolB specifically interacts with liganded LolA.
    Title: Large-scale preparation of the homogeneous LolA lipoprotein complex and efficient in vitro transfer of lipoproteins to the outer membrane in a LolB-dependent manner.
  6. LolA and LolB have similar unclosed {beta}-barrel structures
    Title: Mechanisms underlying energy-independent transfer of lipoproteins from LolA to LolB, which have similar unclosed {beta}-barrel structures.
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General gene information

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Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within lipoprotein localization to outer membrane IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in lipoprotein localization to outer membrane IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in lipoprotein localization to outer membrane IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within lipoprotein localization to outer membrane IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within lipoprotein metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cell outer membrane IEA
Inferred from Electronic Annotation
more info
  
located_in outer membrane-bounded periplasmic space IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
outer membrane lipoprotein LolB

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    1262877..1263500 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_415727.1 outer membrane lipoprotein LolB [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_415727.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A1V2GIK3, A0A376MVX2
    Conserved Domains (1) summary
    TIGR00548
    Location:5 → 206
    lolB; outer membrane lipoprotein LolB
Nucleotide Protein
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