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cvrA putative K(+):H(+) antiporter [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 945755, updated on 17-Dec-2024

Summary

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Official Symbol
cvrA
Official Full Name
putative K(+):H(+) antiporter
Primary source
ECOCYC:G6620
Locus tag
b1191
See related
ASAP:ABE-0003999
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK1179; ycgO
Summary
Previously, b4065 (yjcE) and b1191 (ycgO), have been classified as uncharacterized members of the CPA1 family of cation/proton antiport transporters. [More information is available at EcoCyc: G6620].
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Genomic context

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Sequence:
NC_000913.3 (1240335..1242071, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene D-amino acid dehydrogenase Neighboring gene alanine racemase 2 Neighboring gene protein YmgM Neighboring gene murein tetrapeptide carboxypeptidase Neighboring gene lytic murein transglycosylase E

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Growth Inhibition by External Potassium of Escherichia coli Lacking PtsN (EIIANtr) Is Caused by Potassium Limitation Mediated by YcgO. Sharma R, et al. J Bacteriol, 2016 Jul 1. PMID 27137496, Free PMC Article
  2. Deletion of one of two Escherichia coli genes encoding putative Na+/H+ exchangers (ycgO) perturbs cytoplasmic alkali cation balance at low osmolarity. Verkhovskaya ML, et al. Microbiology (Reading), 2001 Nov. PMID 11700351
  3. Potassium/proton antiport system of Escherichia coli. Radchenko MV, et al. J Biol Chem, 2006 Jul 21. PMID 16687400
  4. Genome-wide screening of genes required for swarming motility in Escherichia coli K-12. Inoue T, et al. J Bacteriol, 2007 Feb. PMID 17122336, Free PMC Article
  5. Global topology analysis of the Escherichia coli inner membrane proteome. Daley DO, et al. Science, 2005 May 27. PMID 15919996

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Overproduction of YcgO yields a potassium-sensitive phenotype with similarities to that displayed by the DeltaptsN mutation.
    Title: Growth Inhibition by External Potassium of Escherichia coli Lacking PtsN (EIIANtr) Is Caused by Potassium Limitation Mediated by YcgO.
  2. ChaA K(+)/H(+) antiporter activity enables E. coli to adapt to potassium(+) salinity stress and to maintain potassium homeostasis.
    Title: Potassium/proton antiport system of Escherichia coli.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables antiporter activity IEA
Inferred from Electronic Annotation
more info
  
enables flavin adenine dinucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables potassium:proton antiporter activity IEA
Inferred from Electronic Annotation
more info
  
enables potassium:proton antiporter activity ISO
Inferred from Sequence Orthology
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell volume homeostasis IEA
Inferred from Electronic Annotation
more info
  
involved_in cell volume homeostasis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in potassium ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in potassium ion transport EXP
Inferred from Experiment
more info
 PubMed 
involved_in potassium ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in proton transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISM
Inferred from Sequence Model
more info
 PubMed 

General protein information

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Preferred Names
putative K(+):H(+) antiporter

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    1240335..1242071 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_415709.2 putative K(+):H(+) antiporter [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_415709.2

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A376JXI9
    Conserved Domains (1) summary
    COG3263
    Location:2 → 578
    NhaP2; NhaP-type Na+/H+ and K+/H+ antiporter with C-terminal TrkAC and CorC domains [Energy production and conversion, Inorganic ion transport and metabolism]
Nucleotide Protein
Heading Accession and Version

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