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phoP DNA-binding transcriptional dual regulator PhoP [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 945697, updated on 3-Dec-2024

Summary

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Official Symbol
phoP
Official Full Name
DNA-binding transcriptional dual regulator PhoP
Primary source
ECOCYC:EG10731
Locus tag
b1130
See related
ASAP:ABE-0003807
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK1116
Summary
PhoPQ has been primarily characterized in Salmonella, with significant differences from Escherichia coli. [More information is available at EcoGene: EG10731]. Transcriptional regulatory protein PhoP is a member of the two-component regulatory system PhoQ/PhoP. [More information is available at EcoCyc: EG10731].
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Genomic context

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Sequence:
NC_000913.3 (1189776..1190447, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene peptidase T Neighboring gene 50S ribosomal protein L16-arginine 3-hydroxylase Neighboring gene sensor histidine kinase PhoQ Neighboring gene adenylosuccinate lyase Neighboring gene lysogenization regulator

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Crystal structures of the receiver domain of the response regulator PhoP from Escherichia coli in the absence and presence of the phosphoryl analog beryllofluoride. Bachhawat P, et al. J Bacteriol, 2007 Aug. PMID 17545283, Free PMC Article
  2. Molecular genetic analysis of the Escherichia coli phoP locus. Groisman EA, et al. J Bacteriol, 1992 Jan. PMID 1530848, Free PMC Article
  3. Identifying promoter features of co-regulated genes with similar network motifs. Harari O, et al. BMC Bioinformatics, 2009 Apr 29. PMID 19426448, Free PMC Article
  4. Osmosensing by the bacterial PhoQ/PhoP two-component system. Yuan J, et al. Proc Natl Acad Sci U S A, 2017 Dec 12. PMID 29183977, Free PMC Article
  5. The H box-harboring domain is key to the function of the Salmonella enterica PhoQ Mg2+-sensor in the recognition of its partner PhoP. Castelli ME, et al. J Biol Chem, 2003 Jun 27. PMID 12702718

See all (55) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. data suggest that MgrB affects the acid resistance of E. coli by modulating the expression of iraM, but not completely through PhoP/Q.
    Title: MgrB affects the acid stress response of Escherichia coli by modulating the expression of iraM.
  2. findings directly link the PhoQ/PhoP two-component system to bacterial osmosensing
    Title: Osmosensing by the bacterial PhoQ/PhoP two-component system.
  3. Both MicA and GcvB bind phoPQ mRNA in vivo and in vitro around the translation initiation region of phoP. Binding of either small RNA is sufficient to inhibit ribosome binding and induce mRNA degradation
    Title: Post-transcriptional control of the Escherichia coli PhoQ-PhoP two-component system by multiple sRNAs involves a novel pairing region of GcvB.
  4. Taken together, these results demonstrate that a decrease in the oxidizing activity of the periplasm stimulates PhoQ/PhoP and may reveal a new input stimulus for this important two-component system.
    Title: Perturbation of the oxidizing environment of the periplasm stimulates the PhoQ/PhoP system in Escherichia coli.
  5. MicA directly pairs with phoPQ mRNA in the translation initiation region of phoP and presumably inhibits translation by competing with ribosome binding.
    Title: MicA sRNA links the PhoP regulon to cell envelope stress.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription activator activity IPI
Inferred from Physical Interaction
more info
 PubMed 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables phosphorelay response regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transcription cis-regulatory region binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transcription cis-regulatory region binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in phosphorelay signal transduction system IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of DNA-templated transcription EXP
Inferred from Experiment
more info
 PubMed 
involved_in regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
part_of protein-DNA complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of protein-DNA complex IPI
Inferred from Physical Interaction
more info
 PubMed 

General protein information

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Preferred Names
DNA-binding transcriptional dual regulator PhoP

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    1189776..1190447 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_415648.1 DNA-binding transcriptional dual regulator PhoP [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_415648.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A5C9AP00, A0A6N8QQX4
    Conserved Domains (1) summary
    PRK10816
    Location:1 → 223
    PRK10816; two-component system response regulator PhoP
Nucleotide Protein
Heading Accession and Version

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