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aroG 3-deoxy-7-phosphoheptulonate synthase, Phe-sensitive [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 945605, updated on 3-Dec-2024

Summary

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Official Symbol
aroG
Official Full Name
3-deoxy-7-phosphoheptulonate synthase, Phe-sensitive
Primary source
ECOCYC:EG10079
Locus tag
b0754
See related
ASAP:ABE-0002560
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK0743
Summary
Expression of aroF and aroG is repressed by the tyrR protein with tyrosine or phenylalanine plus tryptophan, respectively as corepressors The three genes (aroF, aroG and aroH) are widely separated on the coli chromosome. [More information is available at EcoCyc: EG10079].
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Genomic context

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Sequence:
NC_000913.3 (785633..786685)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene nicotinamide riboside transporter Neighboring gene Zn(2(+))/Cd(2(+))/Ni(2(+))/Cu(2(+)) exporter Neighboring gene PF13985 family protein YbgS Neighboring gene 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase Neighboring gene galactose-1-epimerase Neighboring gene galactokinase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Probing the stereochemistry of E. coli 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase (phenylalanine-sensitive)-catalyzed synthesis of KDO 8-P analogues. Sundaram AK, et al. J Org Chem, 2000 Sep 22. PMID 10987918
  2. Studies on 3-deoxy-D-arabinoheptulosonate-7-phosphate synthetase(phe)from Escherichia coli K12. 2. Kinetic properties. Simpson RJ, et al. Eur J Biochem, 1976 Nov 15. PMID 12952
  3. 3-Deoxy-D-arabino-heptulosonate 7-phosphate synthase. Purification and molecular characterization of the phenylalanine-sensitive isoenzyme from Escherichia coli. McCandliss RJ, et al. J Biol Chem, 1978 Jun 25. PMID 26682
  4. Regulation of the Escherichia coli tryptophan operon by early reactions in the aromatic pathway. Held WA, et al. J Bacteriol, 1970 Jan. PMID 4904234, Free PMC Article
  5. Phenylalanine biosynthesis in Escherichia coli K-12: mutants derepressed for chorismate mutase P-prephenate dehydratase. Im SW, et al. J Bacteriol, 1971 Jun. PMID 4934063, Free PMC Article

See all (49) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Data show that 3-Deoxy-d-arabinoheptulosonate-7-phosphate (DAHP) synthase (DAHP synthase) has a dimer-of-dimers homotetrameric structure, and DAHP oxime bound to only one subunit of each tight dimer.
    Title: Potent Inhibition of 3-Deoxy-d-arabinoheptulosonate-7-phosphate (DAHP) Synthase by DAHP Oxime, a Phosphate Group Mimic.
  2. it was demonstrated that the deletion of N-terminus prevents the enzyme from forming a dimeric structure, indicating that the N-terminus of AroG plays a critical role in the formation of the essential tight dimeric structure
    Title: Requirement of the N-terminus for dimer formation of phenylalanine-sensitive 3-deoxy-D-arabino-heptulosonate synthase AroG of Escherichia coli.
  3. the role of metal ion in E. coli DAHP synthase is to position the amino acids with the appropriate geometry required to coordinate and activate the water molecule.
    Title: Insights into the mechanism of 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase (Phe) from Escherichia coli using a transient kinetic analysis.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables 3-deoxy-7-phosphoheptulonate synthase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 3-deoxy-7-phosphoheptulonate synthase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables 3-deoxy-7-phosphoheptulonate synthase activity IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in amino acid biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in aromatic amino acid family biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in aromatic amino acid family biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in chorismate biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
3-deoxy-7-phosphoheptulonate synthase, Phe-sensitive
NP_415275.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    785633..786685
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_415275.1 3-deoxy-7-phosphoheptulonate synthase, Phe-sensitive [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_415275.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A376FP88
    Conserved Domains (1) summary
    PRK09261
    Location:1 → 349
    PRK09261; phospho-2-dehydro-3-deoxyheptonate aldolase; Validated
Nucleotide Protein
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