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iaaA isoaspartyl dipeptidase proenzyme [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 945456, updated on 3-Dec-2024

Summary

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Official Symbol
iaaA
Official Full Name
isoaspartyl dipeptidase proenzyme
Primary source
ECOCYC:EG12407
Locus tag
b0828
See related
ASAP:ABE-0002828
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK0818; spt; ybiK
Summary
IaaA is cleaved before Thr179 to expose N-terminal nucleophile and to produce two subunits. [More information is available at EcoGene: EG12407]. Asparaginase III is first synthesized as a proenzyme which is autocatalytically cleaved post-translationally into two smaller polypeptides. [More information is available at EcoCyc: EG12407].
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Genomic context

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Sequence:
NC_000913.3 (866568..867533)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene molybdopterin-synthase adenylyltransferase Neighboring gene molybdopterin molybdotransferase Neighboring gene glutathione ABC transporter ATP binding subunit GsiA Neighboring gene glutathione ABC transporter periplasmic binding protein Neighboring gene glutathione ABC transporter membrane subunit GsiC

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Crystal packing of plant-type L-asparaginase from Escherichia coli. Michalska K, et al. Acta Crystallogr D Biol Crystallogr, 2008 Mar. PMID 18323626
  2. Crystallization and preliminary crystallographic studies of a new L-asparaginase encoded by the Escherichia coli genome. Borek D, et al. Acta Crystallogr D Biol Crystallogr, 2000 Nov. PMID 11053866
  3. Aspartic peptide hydrolases in Salmonella enterica serovar typhimurium. Larsen RA, et al. J Bacteriol, 2001 May. PMID 11325937, Free PMC Article
  4. Isoaspartyl dipeptidase activity of plant-type asparaginases. Hejazi M, et al. Biochem J, 2002 May 15. PMID 11988085, Free PMC Article
  5. Sequence analysis of enzymes with asparaginase activity. Borek D, et al. Acta Biochim Pol, 2001. PMID 11996000

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. results show that residues 195RKH197 of E. coli L-ASP are critical to its antigenicity
    Title: Probing the antigenicity of E. coli L-asparaginase by mutational analysis.
  2. analysis of allosteric regulation of the cytoplasmic Escherichia coli L-asparaginase I
    Title: Crystal structure and allosteric regulation of the cytoplasmic Escherichia coli L-asparaginase I.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables asparaginase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables asparaginase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables beta-aspartyl-peptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables beta-aspartyl-peptidase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables beta-aspartyl-peptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables peptidase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within protein autoprocessing IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
isoaspartyl dipeptidase proenzyme
NP_415349.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    866568..867533
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_415349.1 isoaspartyl dipeptidase proenzyme [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_415349.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A8T6BNS7
    Conserved Domains (1) summary
    PRK10226
    Location:1 → 313
    PRK10226; isoaspartyl peptidase; Provisional
Nucleotide Protein
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