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lsrB Autoinducer-2 ABC transporter periplasmic binding protein [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 945418, updated on 17-Dec-2024

Summary

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Official Symbol
lsrB
Official Full Name
Autoinducer-2 ABC transporter periplasmic binding protein
Primary source
ECOCYC:G6803
Locus tag
b1516
See related
ASAP:ABE-0005063
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK1509; yneA
Summary
Salmonella LsrB binds a chemically distinct form of the AI-2 signal, (2R,4S)-2-methyl-2,3,3,4-tetrahydroxytetrahydrofuran (R-THMF), that lacks the boron found in Vibrio AI-2. [More information is available at EcoGene: EG13809]. LsrB is a periplasmic binding protein of a predicted ATP-dependent sugar transporter. [More information is available at EcoCyc: G6803].
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Genomic context

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Sequence:
NC_000913.3 (1605051..1606073)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene Autoinducer-2 ABC transporter ATP binding subunit Neighboring gene Autoinducer-2 ABC transporter membrane subunit LsrC Neighboring gene Autoinducer-2 ABC transporter membrane subunit LsrD Neighboring gene 3-hydroxy-2,4-pentadione 5-phosphate thiolase Neighboring gene (4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Identification of functional LsrB-like autoinducer-2 receptors. Pereira CS, et al. J Bacteriol, 2009 Nov. PMID 19749048, Free PMC Article
  2. Salmonella typhimurium recognizes a chemically distinct form of the bacterial quorum-sensing signal AI-2. Miller ST, et al. Mol Cell, 2004 Sep 10. PMID 15350213
  3. Chemotaxis to the quorum-sensing signal AI-2 requires the Tsr chemoreceptor and the periplasmic LsrB AI-2-binding protein. Hegde M, et al. J Bacteriol, 2011 Feb. PMID 21097621, Free PMC Article
  4. The LuxS-dependent autoinducer AI-2 controls the expression of an ABC transporter that functions in AI-2 uptake in Salmonella typhimurium. Taga ME, et al. Mol Microbiol, 2001 Nov. PMID 11722742
  5. Regulation of uptake and processing of the quorum-sensing autoinducer AI-2 in Escherichia coli. Xavier KB, et al. J Bacteriol, 2005 Jan. PMID 15601708, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Both LsrB and Tsr are necessary for sensing AI-2, but AI-2 uptake is not, suggesting that LsrB and Tsr interact directly in the periplasm.
    Title: Chemotaxis to the quorum-sensing signal AI-2 requires the Tsr chemoreceptor and the periplasmic LsrB AI-2-binding protein.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by EcoCyc

Process Evidence Code Pubs
involved_in autoinducer AI-2 transmembrane transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in autoinducer AI-2 transmembrane transport NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in quorum sensing NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of ATP-binding cassette (ABC) transporter complex IEA
Inferred from Electronic Annotation
more info
  
part_of ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing NAS
Non-traceable Author Statement
more info
 PubMed 
located_in membrane NAS
Non-traceable Author Statement
more info
 PubMed 
located_in periplasmic space IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Autoinducer-2 ABC transporter periplasmic binding protein
NP_416033.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    1605051..1606073
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_416033.1 Autoinducer-2 ABC transporter periplasmic binding protein [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_416033.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A5B9AK37, A0A8S7EHN6
    Conserved Domains (1) summary
    PRK15408
    Location:5 → 340
    PRK15408; autoinducer 2 ABC transporter substrate-binding protein LsrB
Nucleotide Protein
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