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galE UDP-glucose 4-epimerase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 945354, updated on 3-Dec-2024

Summary

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Official Symbol
galE
Official Full Name
UDP-glucose 4-epimerase
Primary source
ECOCYC:EG10362
Locus tag
b0759
See related
ASAP:ABE-0002575
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK0748; galD
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Genomic context

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Sequence:
NC_000913.3 (791039..792055, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene galactose-1-epimerase Neighboring gene galactokinase Neighboring gene galactose-1-phosphate uridylyltransferase Neighboring gene ABC family protein ModF Neighboring gene DNA-binding transcriptional dual regulator ModE

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Crystal structures of the oxidized and reduced forms of UDP-galactose 4-epimerase isolated from Escherichia coli. Thoden JB, et al. Biochemistry, 1996 Feb 27. PMID 8611559
  2. UDP-galactose 4-epimerase. Phosphorus-31 nuclear magnetic resonance analysis of NAD+ and NADH bound at the active site. Konopka JM, et al. Biochemistry, 1989 Mar 21. PMID 2659075
  3. Translation of galE and coordination of galactose operon expression in Escherichia coli: effects of insertions and deletions in the non-translated leader sequence. Bingham AH, et al. Mol Microbiol, 1987 Jul. PMID 2838723
  4. An arginine residue is essential for stretching and binding of the substrate on UDP-glucose-4-epimerase from Escherichia coli. Use of a stacked and quenched uridine nucleotide fluorophore as probe. Bhattacharyya U, et al. J Biol Chem, 1999 May 21. PMID 10329648
  5. Dramatic differences in the binding of UDP-galactose and UDP-glucose to UDP-galactose 4-epimerase from Escherichia coli. Thoden JB, et al. Biochemistry, 1998 Aug 18. PMID 9708982

See all (94) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Reduced susceptibility to antiseptics is conferred by heterologous housekeeping genes, fabI and galE.
    Title: Reduced Susceptibility to Antiseptics Is Conferred by Heterologous Housekeeping Genes.
  2. co-translational maturation of the GalE N-terminal domain influences ribosome pausing and subsequent tmRNA activity
    Title: The N-terminus of GalE induces tmRNA activity in Escherichia coli.
  3. N-terminus verified by Edman degradation on complete protein
    Title: Amounts of proteins altered by mutations in the dnaA gene of Escherichia coli.
  4. we located the traditional galE gene in the gal operon of O86:B7, which can catalyze the interconversion of UDP-Glc to UDP-Gal.
    Title: Three UDP-hexose 4-epimerases with overlapping substrate specificity coexist in E. coli O86:B7.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables NAD+ binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables UDP-glucose 4-epimerase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables UDP-glucose 4-epimerase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables UDP-glucose 4-epimerase activity IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables isomerase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables racemase and epimerase activity, acting on carbohydrates and derivatives IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within carbohydrate metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within colanic acid biosynthetic process IEP
Inferred from Expression Pattern
more info
 PubMed 
acts_upstream_of_or_within colanic acid biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within galactose catabolic process via UDP-galactose IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within galactose metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in galactose metabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within galactose metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in monosaccharide metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol HDA PubMed 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
UDP-glucose 4-epimerase
NP_415280.3

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    791039..792055 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_415280.3 UDP-glucose 4-epimerase [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_415280.3

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A765X5B7
    Conserved Domains (1) summary
    PRK10675
    Location:1 → 338
    PRK10675; UDP-galactose-4-epimerase; Provisional
Nucleotide Protein
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