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sucD succinyl-CoA synthetase subunit alpha [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 945314, updated on 3-Dec-2024

Summary

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Official Symbol
sucD
Official Full Name
succinyl-CoA synthetase subunit alpha
Primary source
ECOCYC:EG10982
Locus tag
b0729
See related
ASAP:ABE-0002485
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK0717
Summary
sucCD is a synthetic lethal with sucAB. [More information is available at EcoGene: EG10982]. contains the his residue that is phosphorylated. [More information is available at EcoCyc: EG10982].
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Genomic context

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Sequence:
NC_000913.3 (764180..765049)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene dihydrolipoyltranssuccinylase Neighboring gene succinyl-CoA synthetase subunit beta Neighboring gene ncRNA Neighboring gene DNA-binding transcriptional repressor MngR

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Site-directed mutagenesis of Escherichia coli succinyl-CoA synthetase. Histidine 142 alpha is a facilitative catalytic residue. Luo GX, et al. J Biol Chem, 1991 Nov 5. PMID 1939128
  2. Participation of Cys123alpha of Escherichia coli succinyl-CoA synthetase in catalysis. Hidber E, et al. Acta Crystallogr D Biol Crystallogr, 2007 Aug. PMID 17642514
  3. The subunits of succinyl-coenzyme A synthetase--function and assembly. Bridger WA, et al. Biochem Soc Symp, 1987. PMID 3332988
  4. The crystal structure of succinyl-CoA synthetase from Escherichia coli at 2.5-A resolution. Wolodko WT, et al. J Biol Chem, 1994 Apr 8. PMID 8144675
  5. Probing the nucleotide-binding site of Escherichia coli succinyl-CoA synthetase. Joyce MA, et al. Biochemistry, 1999 Jun 1. PMID 10353839

See all (36) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. N-terminus verified by Edman degradation on mature peptide
    Title: Comparing the predicted and observed properties of proteins encoded in the genome of Escherichia coli K-12.
  2. explain why this cysteine residue is conserved in the sequences of succinyl-CoA synthetases from different sources
    Title: Participation of Cys123alpha of Escherichia coli succinyl-CoA synthetase in catalysis.
  3. sucAB and sucCD are mutually essential genes for production of succinyl Coa that is essential for cell viability
    Title: sucAB and sucCD are mutually essential genes in Escherichia coli.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
  
enables ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables succinate-CoA ligase (ADP-forming) activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables succinate-CoA ligase (ADP-forming) activity IEA
Inferred from Electronic Annotation
more info
  
enables succinate-CoA ligase (GDP-forming) activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables succinate-CoA ligase (GDP-forming) activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in tricarboxylic acid cycle IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in tricarboxylic acid cycle IEA
Inferred from Electronic Annotation
more info
  
involved_in tricarboxylic acid cycle NAS
Non-traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm HDA PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
part_of succinate-CoA ligase complex (ADP-forming) IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of succinate-CoA ligase complex (ADP-forming) IDA
Inferred from Direct Assay
more info
 PubMed 
part_of succinate-CoA ligase complex (ADP-forming) IPI
Inferred from Physical Interaction
more info
 PubMed 

General protein information

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Preferred Names
succinyl-CoA synthetase subunit alpha
NP_415257.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    764180..765049
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_415257.1 succinyl-CoA synthetase subunit alpha [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_415257.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A8S0FYB1
    Conserved Domains (1) summary
    PRK05678
    Location:1 → 289
    PRK05678; succinyl-CoA synthetase subunit alpha; Validated
Nucleotide Protein
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