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paoC aldehyde dehydrogenase: molybdenum cofactor-binding subunit [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 944961, updated on 3-Dec-2024

Summary

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Official Symbol
paoC
Official Full Name
aldehyde dehydrogenase: molybdenum cofactor-binding subunit
Primary source
ECOCYC:G6155
Locus tag
b0284
See related
ASAP:ABE-0000988
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK0283; yagR
Summary
AFMB Structural Genomics target Number 101 (http://afmb.cnrs-mrs.fr/article171.html). [More information is available at EcoGene: EG13557]. A YagR-YagS-YagT complex may be a heterotrimeric xanthine dehydrogenase . [More information is available at EcoCyc: G6155].
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Genomic context

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Sequence:
NC_000913.3 (298736..300934, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene putative phage integrase Neighboring gene putative LysR family substrate binding domain-containing protein YagP Neighboring gene molybdenum cofactor insertion chaperone PaoD Neighboring gene aldehyde dehydrogenase, FAD-binding subunit Neighboring gene aldehyde dehydrogenase, Fe-S subunit Neighboring gene DUF1440 domain-containing inner membrane protein YagU

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Identification of a Rhodobacter capsulatus L-cysteine desulfurase that sulfurates the molybdenum cofactor when bound to XdhC and before its insertion into xanthine dehydrogenase. Neumann M, et al. Biochemistry, 2007 Aug 21. PMID 17649978
  2. A periplasmic aldehyde oxidoreductase represents the first molybdopterin cytosine dinucleotide cofactor containing molybdo-flavoenzyme from Escherichia coli. Neumann M, et al. FEBS J, 2009 May. PMID 19368556
  3. Molybdenum cofactor-dependent resistance to N-hydroxylated base analogs in Escherichia coli is independent of MobA function. Kozmin SG, et al. Mutat Res, 2007 Jun 1. PMID 17349664, Free PMC Article
  4. Over 1000 genes are involved in the DNA damage response of Escherichia coli. Khil PP, et al. Mol Microbiol, 2002 Apr. PMID 11967071
  5. The Escherichia coli Periplasmic Aldehyde Oxidoreductase Is an Exceptional Member of the Xanthine Oxidase Family of Molybdoenzymes. Correia MA, et al. ACS Chem Biol, 2016 Oct 21. PMID 27622978

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables carboxylate reductase activity IEA
Inferred from Electronic Annotation
more info
  
enables iron ion binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables molybdenum ion binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables oxidoreductase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity, acting on the aldehyde or oxo group of donors IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within DNA damage response IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in cellular detoxification of aldehyde IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in outer membrane-bounded periplasmic space NAS
Non-traceable Author Statement
more info
 PubMed 
part_of oxidoreductase complex IPI
Inferred from Physical Interaction
more info
 PubMed 
located_in periplasmic space IEA
Inferred from Electronic Annotation
more info
  
located_in periplasmic space NAS
Non-traceable Author Statement
more info
 PubMed 

General protein information

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Preferred Names
aldehyde dehydrogenase: molybdenum cofactor-binding subunit
NP_414818.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    298736..300934 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_414818.1 aldehyde dehydrogenase: molybdenum cofactor-binding subunit [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_414818.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A376L1K7, A0A8S7TGW1
    Conserved Domains (1) summary
    COG1529
    Location:13 → 730
    CoxL; CO or xanthine dehydrogenase, Mo-binding subunit [Energy production and conversion]
Nucleotide Protein
Heading Accession and Version

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