U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

fabZ 3-hydroxy-acyl-[acyl-carrier-protein] dehydratase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 944888, updated on 3-Dec-2024

Summary

Go to the top of the page Help
Official Symbol
fabZ
Official Full Name
3-hydroxy-acyl-[acyl-carrier-protein] dehydratase
Primary source
ECOCYC:EG11284
Locus tag
b0180
See related
ASAP:ABE-0000613
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK0179; sabA1; sefA; sfhC21; yaeA
Summary
Binds TrxA (Kumar, 2004). [More information is available at EcoGene: EG11284]. Certain mutations in fabZ have been found as suppressor mutations; its sabA1 allele changes the suppression of the OmpF315 phenotype by asmB1, and increased fabZ expression suppresses OmpF315 itself . [More information is available at EcoCyc: EG11284].
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Sequence:
NC_000913.3 (202101..202556)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene periplasmic chaperone Skp Neighboring gene UDP-3-O-(3-hydroxymyristoyl)glucosamine N-acyltransferase Neighboring gene acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase Neighboring gene lipid A disaccharide synthase Neighboring gene RNase HII

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Septum formation-defective mutant of Escherichia coli. Normark S, et al. J Bacteriol, 1976 Oct. PMID 789345, Free PMC Article
  2. An Escherichia coli gene (FabZ) encoding (3R)-hydroxymyristoyl acyl carrier protein dehydrase. Relation to fabA and suppression of mutations in lipid A biosynthesis. Mohan S, et al. J Biol Chem, 1994 Dec 30. PMID 7806516
  3. Insertion mutagenesis of the gene encoding the ferrichrome-iron receptor of Escherichia coli K-12. Carmel G, et al. J Bacteriol, 1990 Apr. PMID 2156805, Free PMC Article
  4. Induction of Escherichia coli hydroperoxidase I by acetate and other weak acids. Mukhopadhyay S, et al. J Bacteriol, 1994 Apr. PMID 8157598, Free PMC Article
  5. Molecular characterization of enterobacterial pldA genes encoding outer membrane phospholipase A. Brok RG, et al. J Bacteriol, 1994 Feb. PMID 8300539, Free PMC Article

See all (34) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The fused dimer of FabZ (FabZ-FabZ) was expressed as a soluble enzyme with an ninefold higher activity in vitro than the unfused FabZ.
    Title: Fused dimerization increases expression, solubility, and activity of bacterial dehydratase enzymes.
  2. N-terminus verified by Edman degradation on complete protein
    Title: Purification and characterization of an 'actomyosin' complex from Escherichia coli W3110.
Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables (3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables (3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydro-lyase activity IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables lyase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within fatty acid biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in fatty acid biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in lipid A biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
3-hydroxy-acyl-[acyl-carrier-protein] dehydratase
NP_414722.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    202101..202556
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_414722.1 3-hydroxy-acyl-[acyl-carrier-protein] dehydratase [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_414722.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A376U2X3
    Conserved Domains (1) summary
    PRK00006
    Location:2 → 150
    fabZ; 3-hydroxyacyl-ACP dehydratase FabZ
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.