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ftsQ cell division protein FtsQ [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 944823, updated on 3-Dec-2024

Summary

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Official Symbol
ftsQ
Official Full Name
cell division protein FtsQ
Primary source
ECOCYC:EG10342
Locus tag
b0093
See related
ASAP:ABE-0000329
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK0094
Summary
Overexpression causes filamentous biofilm formation. [More information is available at EcoGene: EG10342]. FtsQ is an essential cell division protein that is required throughout the process of septum formation; the protein is present in very small amounts of approximately 22 molecules per cell . [More information is available at EcoCyc: EG10342].
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Genomic context

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Sequence:
NC_000913.3 (103155..103985)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene peptidoglycan glycosyltransferase FtsW Neighboring gene N-acetylglucosaminyl transferase Neighboring gene UDP-N-acetylmuramate--L-alanine ligase Neighboring gene D-alanine--D-alanine ligase B Neighboring gene cell division protein FtsA Neighboring gene cell division protein FtsZ Neighboring gene UDP-3-O-acyl-N-acetylglucosamine deacetylase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. An amino-proximal domain required for the localization of FtsQ in the cytoplasmic membrane, and for its biological function in Escherichia coli. Dopazo A, et al. Mol Microbiol, 1992 Mar. PMID 1574000
  2. Analysis of ftsQ mutant alleles in Escherichia coli: complementation, septal localization, and recruitment of downstream cell division proteins. Chen JC, et al. J Bacteriol, 2002 Feb. PMID 11790739, Free PMC Article
  3. Localization of cell division protein FtsQ by immunofluorescence microscopy in dividing and nondividing cells of Escherichia coli. Buddelmeijer N, et al. J Bacteriol, 1998 Dec. PMID 9829918, Free PMC Article
  4. The ftsQ1p gearbox promoter of Escherichia coli is a major sigma S-dependent promoter in the ddlB-ftsA region. Ballesteros M, et al. Mol Microbiol, 1998 Oct. PMID 9791185
  5. Genetic reporter system for positioning of proteins at the bacterial pole. Fixen KR, et al. mBio, 2012. PMID 22375072, Free PMC Article

See all (98) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The structural dynamics of full-length divisome transmembrane proteins FtsQ, FtsB, and FtsL in FtsQBL complex formation.
    Title: The structural dynamics of full-length divisome transmembrane proteins FtsQ, FtsB, and FtsL in FtsQBL complex formation.
  2. Crystal structure of FtsB bound to the beta domain of FtsQ shows that only residues 64 to 87 of FtsB interact with FtsQ.
    Title: Structural Analysis of the Interaction between the Bacterial Cell Division Proteins FtsQ and FtsB.
  3. results support a model in which FtsL, along with its partners FtsB and FtsQ, function as part of a sensing mechanism that promotes the onset of cell wall remodeling processes.
    Title: A role for the FtsQLB complex in cytokinetic ring activation revealed by an ftsL allele that accelerates division.
  4. results suggest that the FtsQ interaction with FtsN, although not strictly essential for the division process, at least in some conditions, plays a role in the proper formation or stability of the division machinery
    Title: Essential and non-essential interactions in interactome networks: the Escherichia coli division proteins FtsQ-FtsN interaction.
  5. show that the conserved cell division protein FtsQ is required for localization of IcsA and other autotransporters to the pole.
    Title: Genetic reporter system for positioning of proteins at the bacterial pole.
  6. A structural model was developed for the periplasmic part of the FtsB/FtsL/FtsQ complex.
    Title: A model for the Escherichia coli FtsB/FtsL/FtsQ cell division complex.
  7. Results allow the identification of FtsQ residues involved in the interaction with other partner proteins and the determination of the biological significance of these interactions.
    Title: FtsQ interaction mutants: a way to identify new antibacterial targets.
  8. Study find that, as with FtsB, the C terminus of FtsL is required for the interaction of FtsQ with the FtsB/FtsL subcomplex while the cytoplasmic domain of FtsL is involved in recruitment of the downstream division proteins.
    Title: Multiple interaction domains in FtsL, a protein component of the widely conserved bacterial FtsLBQ cell division complex.
  9. Our results indicate that the FtsQ TMS plays a role in FtsQ localization to the division site.
    Title: Contribution of the FtsQ transmembrane segment to localization to the cell division site.
  10. FtsQ is associated in a hierarchical set of protein complexes and its assembly can occur independently of 'upstream' proteins.
    Title: Premature targeting of cell division proteins to midcell reveals hierarchies of protein interactions involved in divisome assembly.
Submit: New GeneRIF Correction See all GeneRIFs (11)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in FtsZ-dependent cytokinesis IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within FtsZ-dependent cytokinesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in FtsZ-dependent cytokinesis NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in cell division IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cell division IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cell division NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in cell septum assembly IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within division septum assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in division septum assembly NAS
Non-traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
part_of FtsQBL complex IPI
Inferred from Physical Interaction
more info
 PubMed 
located_in cell division site IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cell division site IEA
Inferred from Electronic Annotation
more info
  
located_in cell division site NAS
Non-traceable Author Statement
more info
 PubMed 
part_of divisome complex NAS
Non-traceable Author Statement
more info
 PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IMP
Inferred from Mutant Phenotype
more info
 PubMed 
located_in plasma membrane NAS
Non-traceable Author Statement
more info
 PubMed 

General protein information

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Preferred Names
cell division protein FtsQ

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    103155..103985
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_414635.1 cell division protein FtsQ [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_414635.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A377DF54
    Conserved Domains (1) summary
    PRK10775
    Location:1 → 264
    PRK10775; cell division protein FtsQ; Provisional
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

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