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Fez2 fasciculation and elongation protein zeta 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 94269, updated on 27-Nov-2024

Summary

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Official Symbol
Fez2provided by RGD
Official Full Name
fasciculation and elongation protein zeta 2provided by RGD
Primary source
RGD:619709
See related
EnsemblRapid:ENSRNOG00000004577 AllianceGenome:RGD:619709
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Zrp
Summary
Predicted to be involved in negative regulation of autophagosome assembly. Predicted to be active in axon and cytoplasm. Orthologous to human FEZ2 (fasciculation and elongation protein zeta 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Heart (RPKM 121.3), Muscle (RPKM 117.0) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Fez2 in Genome Data Viewer
Location:
6q12
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (22406685..22446745)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (16654572..16694628)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (963903..1003955, complement)

Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene striatin Neighboring gene vitrin Neighboring gene U2 spliceosomal RNA Neighboring gene cysteine rich transmembrane BMP regulator 1 Neighboring gene uncharacterized LOC120103478 Neighboring gene NSA2 ribosome biogenesis factor, pseudogene 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. mRNA expression of membrane-fusion-related proteins in rat parotid gland. Imai A, et al. Arch Oral Biol, 2001 Oct. PMID 11451410
  2. Identification of a tissue-non-specific homologue of axonal fasciculation and elongation protein zeta-1. Fujita T, et al. Biochem Biophys Res Commun, 2004 Jan 16. PMID 14697253
  3. RAB3GAP1 and RAB3GAP2 modulate basal and rapamycin-induced autophagy. Spang N, et al. Autophagy, 2014. PMID 25495476, Free PMC Article
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. FEZ2 plays an important role in the morphological changes of various cells by associating with PKCzeta in a tissue-non-specific manner
    Title: Identification of a tissue-non-specific homologue of axonal fasciculation and elongation protein zeta-1.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Clone Names

  • MGC112579

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in negative regulation of autophagosome assembly IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of autophagosome assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of autophagosome assembly ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of exocytosis TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
is_active_in axon IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
fasciculation and elongation protein zeta-2
Names
synaptotagmin interacting protein zyginII
zygin II
zygin-2
zygin-related protein types I/II

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001414905.1 → NP_001401834.1  fasciculation and elongation protein zeta-2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000006
    UniProtKB/TrEMBL
    Q498V3

  2. NM_053600.3 → NP_446052.2  fasciculation and elongation protein zeta-2 isoform 1

    See identical proteins and their annotated locations for NP_446052.2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000006
    UniProtKB/Swiss-Prot
    P97578, Q76LN1, Q9JJ35, Q9JJ36
    UniProtKB/TrEMBL
    A6H9W4
    Related
    ENSRNOP00000075253.3, ENSRNOT00000082071.3
    Conserved Domains (1) summary
    pfam07763
    Location:42 → 265
    FEZ; FEZ-like protein

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086024.1 Reference GRCr8

    Range
    22406685..22446745
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063262567.1 → XP_063118637.1  fasciculation and elongation protein zeta-2 isoform X2

  2. XM_006239639.5 → XP_006239701.3  fasciculation and elongation protein zeta-2 isoform X1

    UniProtKB/TrEMBL
    F7EYQ2
    Conserved Domains (1) summary
    pfam07763
    Location:66 → 289
    FEZ; FEZ-like protein

RNA

  1. XR_010052153.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P97578.2 GenPept UniProtKB/Swiss-Prot:P97578

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials