Cnnm4 cyclin M4 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cnnm4provided by MGI
Official Full Name: cyclin M4provided by MGI
Primary source: MGI:MGI:2151060
See related: Ensembl:ENSMUSG00000037408 AllianceGenome:MGI:2151060
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Acdp4; 5430430O18Rik
Summary: Enables magnesium ion transmembrane transporter activity and sodium ion transmembrane transporter activity. Acts upstream of or within enamel mineralization; magnesium ion homeostasis; and magnesium ion transport. Located in basolateral plasma membrane. Is expressed in colon and metanephros. Human ortholog(s) of this gene implicated in Jalili syndrome. Orthologous to human CNNM4 (cyclin and CBS domain divalent metal cation transport mediator 4). [provided by Alliance of Genome Resources, Jan 2025]
Expression: Biased expression in colon adult (RPKM 97.1), large intestine adult (RPKM 49.6) and 6 other tissues See more
Orthologs: human all
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Genomic context

Location:: 1 B; 1 15.28 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (36510678..36547857)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (36471597..36508776)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Restoring cellular magnesium balance through Cyclin M4 protects against acetaminophen-induced liver damage.
Title: Restoring cellular magnesium balance through Cyclin M4 protects against acetaminophen-induced liver damage.
The importance of CNNM4 in maintaining the normal balance between cell proliferation and differentiation in the colon epithelia.
Title: Cnnm4 deficiency suppresses Ca(2+) signaling and promotes cell proliferation in the colon epithelia.
These results suggest a new role of CNNM4 in sperm Ca(2+) homeostasis.
Title: The Mg2+ transporter CNNM4 regulates sperm Ca2+ homeostasis and is essential for reproduction.
these results indicate that CNNM4-dependent Mg(2+) efflux suppresses tumor progression by regulating energy metabolism.
Title: Membrane protein CNNM4-dependent Mg2+ efflux suppresses tumor progression.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (4) 1 citation

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables magnesium ion transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables magnesium ion transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables sodium ion transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables sodium ion transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within enamel mineralization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intracellular monoatomic cation homeostasis	IEA Inferred from Electronic Annotation more info
involved_in intracellular monoatomic cation homeostasis	ISO Inferred from Sequence Orthology more info
involved_in magnesium ion homeostasis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within magnesium ion homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in magnesium ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in magnesium ion transport	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within magnesium ion transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sodium ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in visual perception	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in basolateral plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in dendrite	ISO Inferred from Sequence Orthology more info
located_in neuronal cell body	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
part_of protein-containing complex	IEA Inferred from Electronic Annotation more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: metal transporter CNNM4

Names: ancient conserved domain protein 4; ancient conserved domain-containing protein 4; mACDP4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_033570.2 → NP_291048.2 metal transporter CNNM4 precursor

See identical proteins and their annotated locations for NP_291048.2

Status: VALIDATED

Source sequence(s)

AK164200, AK173209, CJ168962

Consensus CDS

CCDS14879.2

UniProtKB/Swiss-Prot

Q69ZF7, Q9JIM7

UniProtKB/TrEMBL

D3Y2F8

Related

ENSMUSP00000121317.2, ENSMUST00000153128.2

Conserved Domains (3) summary

COG0517
Location:370 → 497

CBS; CBS domain [Signal transduction mechanisms]

cd04590
Location:379 → 499

CBS_pair_CorC_HlyC_assoc; This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in ...

pfam01595
Location:193 → 355

DUF21; Domain of unknown function DUF21