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Spp2 secreted phosphoprotein 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 94168, updated on 27-Nov-2024

Summary

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Official Symbol
Spp2provided by RGD
Official Full Name
secreted phosphoprotein 2provided by RGD
Primary source
RGD:708488
See related
EnsemblRapid:ENSRNOG00000053244 AllianceGenome:RGD:708488
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Involved in protein-containing complex assembly. Part of protein-containing complex. Orthologous to human SPP2 (secreted phosphoprotein 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Liver (RPKM 4294.6) and Kidney (RPKM 1052.4) See more
Orthologs
human mouse all
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Genomic context

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See Spp2 in Genome Data Viewer
Location:
9q35
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (96454636..96474453)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (89006858..89026676)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (95501512..95509646)

Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene transient receptor potential cation channel, subfamily M, member 8 Neighboring gene uncharacterized LOC108351971 Neighboring gene small nucleolar RNA SNORA17 Neighboring gene uncharacterized LOC102554187 Neighboring gene uncharacterized LOC120094852

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. A new inositol 1,4,5-trisphosphate binding protein similar to phospholipase C-delta 1. Kanematsu T, et al. Biochem J, 1996 Jan 1. PMID 8546702, Free PMC Article
  2. Isolation and molecular cloning of a novel bone phosphoprotein related in sequence to the cystatin family of thiol protease inhibitors. Hu B, et al. J Biol Chem, 1995 Jan 6. PMID 7814406
  3. Biochemical characterization of the serum fetuin-mineral complex. Price PA, et al. J Biol Chem, 2003 Jun 13. PMID 12676928
  4. Characterization of the human secreted phosphoprotein 24 gene (SPP2) and comparison of the protein sequence in nine species. Bennett CS, et al. Matrix Biol, 2004 Feb. PMID 15062857
  5. Glycoproteomics Reveals Decorin Peptides With Anti-Myostatin Activity in Human Atrial Fibrillation. Barallobre-Barreiro J, et al. Circulation, 2016 Sep 13. PMID 27559042, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC108864

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in bone remodeling IEA
Inferred from Electronic Annotation
more info
  
involved_in protein-containing complex assembly IPI
Inferred from Physical Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
part_of protein-containing complex IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
secreted phosphoprotein 24
Names
secreted phosphoprotein 2, 24kDa
spp-24

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_053577.1 → NP_446029.1  secreted phosphoprotein 24 precursor

    See identical proteins and their annotated locations for NP_446029.1

    Status: PROVISIONAL

    Source sequence(s)
    BC088193
    UniProtKB/Swiss-Prot
    Q5M874, Q62740
    UniProtKB/TrEMBL
    A6JQJ4
    Related
    ENSRNOP00000075164.3, ENSRNOT00000086805.3
    Conserved Domains (2) summary
    pfam07448
    Location:67 → 129
    Spp-24; Secreted phosphoprotein 24 (Spp-24) cystatin-like domain
    cl09238
    Location:32 → 100
    CY; Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains.

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086027.1 Reference GRCr8

    Range
    96454636..96474453
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039084306.2 → XP_038940234.1  secreted phosphoprotein 24 isoform X1

    UniProtKB/TrEMBL
    A6JQJ4
    Conserved Domains (2) summary
    pfam07448
    Location:67 → 129
    Spp-24; Secreted phosphoprotein 24 (Spp-24) cystatin-like domain
    cl09238
    Location:32 → 100
    CY; Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q62740.2 GenPept UniProtKB/Swiss-Prot:Q62740

Gene LinkOut

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