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Olfm1 olfactomedin 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 93667, updated on 4-Jan-2025

Summary

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Official Symbol
Olfm1provided by RGD
Official Full Name
olfactomedin 1provided by RGD
Primary source
RGD:620320
See related
EnsemblRapid:ENSRNOG00000009862 AllianceGenome:RGD:620320
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Noe1; D2Sut1e
Summary
Involved in regulation of neurotransmitter receptor localization to postsynaptic specialization membrane. Predicted to be located in several cellular components, including axonal growth cone; neuronal cell body; and synaptic membrane. Predicted to be part of AMPA glutamate receptor complex. Predicted to be active in extracellular space and glutamatergic synapse. Predicted to be extrinsic component of postsynaptic density membrane. Orthologous to human OLFM1 (olfactomedin 1). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Brain (RPKM 633.7), Lung (RPKM 37.6) and 1 other tissue See more
Orthologs
human mouse all
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Genomic context

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See Olfm1 in Genome Data Viewer
Location:
3p12
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (31918512..31956261)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (11520522..11558240)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (6761031..6798739)

Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene collagen type V alpha 1 chain Neighboring gene ficolin B Neighboring gene uncharacterized LOC134486351 Neighboring gene Microtubule-associated proteins 1A/1B light chain 3B-like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Four structurally distinct neuron-specific olfactomedin-related glycoproteins produced by differential promoter utilization and alternative mRNA splicing from a single gene. Danielson PE, et al. J Neurosci Res, 1994 Jul 1. PMID 7932877
  2. Noelin1 Affects Lateral Mobility of Synaptic AMPA Receptors. Pandya NJ, et al. Cell Rep, 2018 Jul 31. PMID 30067977, Free PMC Article
  3. Expression and characterization of disulfide bond use of oligomerized A2-Pancortins: extracellular matrix constituents in the developing brain. Ando K, et al. Neuroscience, 2005. PMID 15927402
  4. Pancortins interact with amyloid precursor protein and modulate cortical cell migration. Rice HC, et al. Development, 2012 Nov. PMID 22992957, Free PMC Article
  5. Olfactomedin 1 interacts with the Nogo A receptor complex to regulate axon growth. Nakaya N, et al. J Biol Chem, 2012 Oct 26. PMID 22923615, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in atrioventricular valve formation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in cardiac epithelial to mesenchymal transition ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of gene expression ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in neuronal signal transduction ISO
Inferred from Sequence Orthology
more info
  
involved_in neuronal signal transduction ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of apoptotic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of epithelial to mesenchymal transition ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of gene expression ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of axon extension ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of axon extension ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of neurotransmitter receptor localization to postsynaptic specialization membrane EXP
Inferred from Experiment
more info
 PubMed 
involved_in regulation of neurotransmitter receptor localization to postsynaptic specialization membrane IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of AMPA glutamate receptor complex ISO
Inferred from Sequence Orthology
more info
  
located_in axon ISO
Inferred from Sequence Orthology
more info
  
located_in axon ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in axonal growth cone ISO
Inferred from Sequence Orthology
more info
  
located_in axonal growth cone ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
  
located_in extracellular space ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in extrinsic component of postsynaptic density membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in extrinsic component of synaptic membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
  
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
  
located_in neuronal cell body ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in perikaryon IEA
Inferred from Electronic Annotation
more info
  
located_in synaptic membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
noelin
Names
1B426B
neuronal olfactomedin-related ER localized protein
olfactomedin related ER localized protein
pancortin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001429602.1 → NP_001416531.1  noelin isoform b precursor

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003
    UniProtKB/TrEMBL
    A6JTM7

  2. NM_001429603.1 → NP_001416532.1  noelin isoform c precursor

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003
    UniProtKB/TrEMBL
    A6JTM4

  3. NM_001429604.1 → NP_001416533.1  noelin isoform d precursor

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003
    UniProtKB/TrEMBL
    A6JTM5

  4. NM_053573.2 → NP_446025.1  noelin isoform a precursor

    See identical proteins and their annotated locations for NP_446025.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003
    UniProtKB/Swiss-Prot
    Q62606, Q62607, Q62608, Q62609
    UniProtKB/TrEMBL
    A6JTM6
    Related
    ENSRNOP00000013443.3, ENSRNOT00000013443.8
    Conserved Domains (3) summary
    smart00284
    Location:228 → 478
    OLF; Olfactomedin-like domains
    PRK03918
    Location:92 → 218
    PRK03918; DNA double-strand break repair ATPase Rad50
    pfam12308
    Location:56 → 152
    Noelin-1; Neurogenesis glycoprotein

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086021.1 Reference GRCr8

    Range
    31918512..31956261
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006233877.4 → XP_006233939.1  noelin isoform X3

    Conserved Domains (1) summary
    pfam12308
    Location:28 → 124
    Noelin-1; Neurogenesis glycoprotein

  2. XM_006233875.4 → XP_006233937.1  noelin isoform X1

    Related
    ENSRNOP00000077356.1, ENSRNOT00000104931.2
    Conserved Domains (3) summary
    smart00284
    Location:200 → 450
    OLF; Olfactomedin-like domains
    PRK03918
    Location:64 → 190
    PRK03918; DNA double-strand break repair ATPase Rad50
    pfam12308
    Location:28 → 124
    Noelin-1; Neurogenesis glycoprotein

  3. XM_006233876.5 → XP_006233938.1  noelin isoform X2

    Related
    ENSRNOP00000060981.3, ENSRNOT00000065953.4
    Conserved Domains (1) summary
    pfam12308
    Location:56 → 152
    Noelin-1; Neurogenesis glycoprotein
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q62609.1 GenPept UniProtKB/Swiss-Prot:Q62609

Gene LinkOut

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