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DMKN dermokine [ Homo sapiens (human) ]

Gene ID: 93099, updated on 27-Nov-2024

Summary

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Official Symbol
DMKNprovided by HGNC
Official Full Name
dermokineprovided by HGNC
Primary source
HGNC:HGNC:25063
See related
Ensembl:ENSG00000161249 MIM:617211; AllianceGenome:HGNC:25063
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
UNQ729; ZD52F10
Summary
This gene is upregulated in inflammatory diseases, and it was first observed as expressed in the differentiated layers of skin. The most interesting aspect of this gene is the differential use of promoters and terminators to generate isoforms with unique cellular distributions and domain components. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jun 2010]
Expression
Biased expression in skin (RPKM 387.3) and esophagus (RPKM 47.0) See more
Orthologs
mouse all
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Genomic context

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See DMKN in Genome Data Viewer
Location:
19q13.12
Exon count:
26
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (35497220..35513649, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (38041938..38058366, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (35988122..36004551, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene keratinocyte differentiation associated protein Neighboring gene uncharacterized LOC124904703 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:35985748-35986694 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:35991019-35991520 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:35991521-35992020 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14482 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:36016123-36016795 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:36017917-36018418 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:36019864-36020364 Neighboring gene suprabasin Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14483 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase, spermatogenic Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:36031035-36031534 Neighboring gene TMEM147 antisense RNA 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:36033929-36034430 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:36036145-36036837

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. The human dermokine gene: description of novel isoforms with different tissue-specific expression and subcellular location. Toulza E, et al. J Invest Dermatol, 2006 Feb. PMID 16374476
  2. Dermokine expression in intraductal papillary-mucinous neoplasm and invasive pancreatic carcinoma. Watanabe K, et al. Anticancer Res, 2012 Oct. PMID 23060565
  3. Dermokine: an extensively differentially spliced gene expressed in epithelial cells. Naso MF, et al. J Invest Dermatol, 2007 Jul. PMID 17380110
  4. The ubiquitous dermokine delta activates Rab5 function in the early endocytic pathway. Leclerc EA, et al. PLoS One, 2011 Mar 10. PMID 21423773, Free PMC Article
  5. Dermokine contributes to epithelial-mesenchymal transition through increased activation of signal transducer and activator of transcription 3 in pancreatic cancer. Huang C, et al. Cancer Sci, 2017 Nov. PMID 28795470, Free PMC Article

See all (31) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. we showed that DMKN loss of function in Patu-8988 and PANC-1 pancreatic cancer cell lines resulted in reduced phosphorylation of STAT3.these data suggested that DMKN could be a potential prognostic biomarker and therapeutic target in pancreatic cancer.
    Title: Dermokine contributes to epithelial-mesenchymal transition through increased activation of signal transducer and activator of transcription 3 in pancreatic cancer.
  2. These results suggest that dermokine-beta delays early cutaneous wound healing in part by inhibiting expression of CXC chemokines containing the ERL-sequence motif.
    Title: Dermokine inhibits ELR(+)CXC chemokine expression and delays early skin wound healing.
  3. Serum DK is a potential biomarker in intraductal papillary mucinous neoplasm and invasive ductal carcinoma, when used in combination with conventional biomarkers.
    Title: Dermokine expression in intraductal papillary-mucinous neoplasm and invasive pancreatic carcinoma.
  4. Dermokine-beta impairs ERK signaling through direct binding to GRP78
    Title: Dermokine-β impairs ERK signaling through direct binding to GRP78.
  5. Dmkndelta activates Rab5 function and thus is involved in the early endosomal trafficking.
    Title: The ubiquitous dermokine delta activates Rab5 function in the early endocytic pathway.
  6. Dermokine gene is expressed in epithelial tissues other than the skin and this expression is transcriptionally and posttranscriptionally complex.
    Title: Dermokine: an extensively differentially spliced gene expressed in epithelial cells.
  7. Analysis of alternative spliced transcripts produced from the dermokine gene.
    Title: The human dermokine gene: description of novel isoforms with different tissue-specific expression and subcellular location.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See Variation Viewer (GRCh37.p13)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ79374

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in cornified envelope assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
dermokine
Names
epidermis-specific secreted protein SK30/SK89

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001035516.4 → NP_001030593.2  dermokine isoform 1 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 2. The encoded isoform (1, also referred to as isoform alpha) has a distinct N-terminus and is shorter than isoform 2.
    Source sequence(s)
    AD001502
    Consensus CDS
    CCDS42549.1
    UniProtKB/TrEMBL
    M0R1M0
    Related
    ENSP00000386225.2, ENST00000408915.6

  2. NM_001126056.3 → NP_001119528.3  dermokine isoform 3 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an alternate in-frame exon and contains three additional alternate in-frame exons in the coding region, compared to variant 2. This results in a shorter protein (isoform 3, also referred to as isoform beta-2), compared to isoform 2.
    Source sequence(s)
    AC138125, AD001502
    Consensus CDS
    CCDS46054.2
    Related
    ENSP00000391036.1, ENST00000419602.5

  3. NM_001126057.3 → NP_001119529.2  dermokine isoform 5 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) differs in the 3' coding region and 3' UTR, compared to variant 2. The resulting isoform (5, also referred to as isoform gamma 2) has a distinct C-terminus and is shorter than isoform 2.
    Source sequence(s)
    AC138125, AY358412, AY789697
    Consensus CDS
    CCDS46053.1
    UniProtKB/Swiss-Prot
    Q6E0U4
    Related
    ENSP00000388404.2, ENST00000424570.6

  4. NM_001126058.3 → NP_001119530.2  dermokine isoform 4 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 3' coding region and 3' UTR, compared to variant 2. The resulting isoform (4, also referred to as isoform gamma 1) has a distinct C-terminus and is shorter than isoform 2.
    Source sequence(s)
    AC138125, AY358412, AY789696
    Consensus CDS
    CCDS46052.1
    UniProtKB/Swiss-Prot
    Q6E0U4
    Related
    ENSP00000414743.1, ENST00000418261.5

  5. NM_001126059.4 → NP_001119531.2  dermokine isoform 6

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 2. The encoded isoform (6, also referred to as isoform delta) has a distinct N-terminus and is shorter than isoform 2.
    Source sequence(s)
    AD001502
    Consensus CDS
    CCDS46051.1
    Related
    ENSP00000392222.2, ENST00000414866.6

  6. NM_001190347.2 → NP_001177276.2  dermokine isoform 8 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8) lacks an alternate in-frame exon and contains two additional alternate in-frame exons in the coding region, compared to variant 2. This results in a shorter protein (isoform 8, also referred to as isoform beta-1), compared to isoform 2.
    Source sequence(s)
    AC138125, AD001502
    Consensus CDS
    CCDS54250.1
    Related
    ENSP00000405503.1, ENST00000429837.5

  7. NM_001190348.2 → NP_001177277.1  dermokine isoform 9 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (9) has multiple difference compared to variant 2. This variant encodes isoform 9, which is shorter than isoform 2.
    Source sequence(s)
    AC138125, AY358412, AY789697, EF158326
    Consensus CDS
    CCDS54252.1
    UniProtKB/Swiss-Prot
    Q6E0U4
    UniProtKB/TrEMBL
    A3EZ84
    Related
    ENSP00000394908.2, ENST00000447113.6

  8. NM_001190349.2 → NP_001177278.1  dermokine isoform 10 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (10) has multiple difference compared to variant 2. This variant encodes isoform 10 (also referred to as isoform gamma 1), which is shorter than isoform 2.
    Source sequence(s)
    AC138125, AY358412, AY789697
    Consensus CDS
    CCDS54251.1
    UniProtKB/Swiss-Prot
    Q6E0U4
    Related
    ENSP00000409513.2, ENST00000451297.6

  9. NM_001308380.2 → NP_001295309.2  dermokine isoform 11

    Status: REVIEWED

    Description
    Transcript Variant: This variant (11) differs in the 5' UTR and has multiple coding region differences, one of which results in use of an alternate start codon and novel 5' coding region compared to variant 2. It encodes isoform 11, which is shorter than and has a distinct N-terminus compared to isoform 2.
    Source sequence(s)
    AD001502
    Consensus CDS
    CCDS77279.1
    UniProtKB/TrEMBL
    C9JCN1, H7BZ95
    Related
    ENSP00000384509.2, ENST00000402589.6

  10. NM_001308383.2 → NP_001295312.2  dermokine isoform 12

    Status: REVIEWED

    Description
    Transcript Variant: This variant (12) differs in the 5' UTR and has multiple coding region differences, one of which results in use of an alternate start codon and novel 5' coding region compared to variant 2. It encodes isoform 12, which is shorter than and has a distinct N-terminus compared to isoform 2.
    Source sequence(s)
    AD001502
    Consensus CDS
    CCDS77278.1
    UniProtKB/TrEMBL
    C9J186
    Related
    ENSP00000412075.1, ENST00000436012.5

  11. NM_001352328.2 → NP_001339257.2  dermokine isoform 13

    Status: REVIEWED

    Source sequence(s)
    AD001502

  12. NM_001352329.2 → NP_001339258.2  dermokine isoform 14

    Status: REVIEWED

    Source sequence(s)
    AD001502
    Consensus CDS
    CCDS86745.1
    UniProtKB/TrEMBL
    S4R3L7
    Related
    ENSP00000473341.2, ENST00000472252.6

  13. NM_001352330.2 → NP_001339259.2  dermokine isoform 14

    Status: REVIEWED

    Source sequence(s)
    AD001502
    Consensus CDS
    CCDS86745.1
    UniProtKB/TrEMBL
    S4R3L7

  14. NM_001352331.2 → NP_001339260.1  dermokine isoform 15

    Status: REVIEWED

    Source sequence(s)
    CD174636, CD388805, EF158325
    Consensus CDS
    CCDS86747.1
    UniProtKB/TrEMBL
    C9J3V3, E9PAQ7
    Related
    ENSP00000376042.2, ENST00000392206.6

  15. NM_001352332.2 → NP_001339261.1  dermokine isoform 16

    Status: REVIEWED

    Source sequence(s)
    CD388805
    Consensus CDS
    CCDS86746.1
    UniProtKB/TrEMBL
    M0R3F8
    Related
    ENSP00000473191.1, ENST00000488892.5

  16. NM_033317.5 → NP_201574.4  dermokine isoform 2 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) represents the longest transcript and encodes the longest isoform (2, also referred to as isoform beta).
    Source sequence(s)
    AC138125, AD001502
    Consensus CDS
    CCDS12463.1
    UniProtKB/Swiss-Prot
    A3EZ79, A3EZ80, A3EZ81, A3EZ82, A3EZ83, C9J4P6, C9J5N8, C9JAL3, Q32W58, Q32W62, Q32W63, Q32W64, Q32W65, Q32W66, Q32W67, Q6E0U4, Q6E0U5, Q6UXC7, Q96EW8, Q9BSY6
    Related
    ENSP00000342012.3, ENST00000339686.8

RNA

  1. NR_033746.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) differs at its 5' end compared to variant 2. This variant is represented as non-coding due to the presence of an upstream ORF that is predicted to interfere with translation of the longest in-frame ORF compared to variant 2; translation of the upstream ORF renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AD001502
    Related
    ENST00000462721.5

  2. NR_147958.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    CD173452, EF158325
    Related
    ENST00000480507.1

  3. NR_147959.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AD001502

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    35497220..35513649 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011527500.3 → XP_011525802.1  dermokine isoform X4

  2. XM_011527501.3 → XP_011525803.1  dermokine isoform X5

  3. XM_011527497.3 → XP_011525799.1  dermokine isoform X3

    See identical proteins and their annotated locations for XP_011525799.1

  4. XM_011527498.3 → XP_011525800.1  dermokine isoform X3

    See identical proteins and their annotated locations for XP_011525800.1

  5. XM_011527495.3 → XP_011525797.1  dermokine isoform X2

    See identical proteins and their annotated locations for XP_011525797.1

  6. XM_047439696.1 → XP_047295652.1  dermokine isoform X14

  7. XM_047439695.1 → XP_047295651.1  dermokine isoform X13

    UniProtKB/Swiss-Prot
    A3EZ79, A3EZ80, A3EZ81, A3EZ82, A3EZ83, C9J4P6, C9J5N8, C9JAL3, Q32W58, Q32W62, Q32W63, Q32W64, Q32W65, Q32W66, Q32W67, Q6E0U4, Q6E0U5, Q6UXC7, Q96EW8, Q9BSY6

  8. XM_047439692.1 → XP_047295648.1  dermokine isoform X11

  9. XM_047439693.1 → XP_047295649.1  dermokine isoform X11

  10. XM_047439689.1 → XP_047295645.1  dermokine isoform X9

  11. XM_047439690.1 → XP_047295646.1  dermokine isoform X9

  12. XM_047439686.1 → XP_047295642.1  dermokine isoform X6

  13. XM_047439694.1 → XP_047295650.1  dermokine isoform X12

  14. XM_047439688.1 → XP_047295644.1  dermokine isoform X8

  15. XM_047439687.1 → XP_047295643.1  dermokine isoform X7

  16. XM_047439685.1 → XP_047295641.1  dermokine isoform X1

  17. XM_047439691.1 → XP_047295647.1  dermokine isoform X10

  18. XM_047439707.1 → XP_047295663.1  dermokine isoform X26

  19. XM_006723489.1 → XP_006723552.1  dermokine isoform X27

    See identical proteins and their annotated locations for XP_006723552.1

    UniProtKB/TrEMBL
    H7BZ95

  20. XM_047439706.1 → XP_047295662.1  dermokine isoform X25

    UniProtKB/TrEMBL
    C9J186

  21. XM_047439705.1 → XP_047295661.1  dermokine isoform X24

  22. XM_047439704.1 → XP_047295660.1  dermokine isoform X23

  23. XM_047439703.1 → XP_047295659.1  dermokine isoform X21

    UniProtKB/TrEMBL
    C9JCN1

  24. XM_047439701.1 → XP_047295657.1  dermokine isoform X20

  25. XM_047439702.1 → XP_047295658.1  dermokine isoform X20

  26. XM_006723484.2 → XP_006723547.1  dermokine isoform X18

    UniProtKB/TrEMBL
    H7BZ95

  27. XM_024451776.2 → XP_024307544.1  dermokine isoform X22

    UniProtKB/TrEMBL
    H7BZ95, M0R0A5
    Related
    ENSP00000471112.1, ENST00000467637.5

  28. XM_047439699.1 → XP_047295655.1  dermokine isoform X19

  29. XM_047439700.1 → XP_047295656.1  dermokine isoform X19

  30. XM_047439698.1 → XP_047295654.1  dermokine isoform X17

  31. XM_047439697.1 → XP_047295653.1  dermokine isoform X16

  32. XM_006723477.2 → XP_006723540.1  dermokine isoform X15

    UniProtKB/TrEMBL
    C9IYI1
    Related
    ENSP00000406864.1, ENST00000443640.5

RNA

  1. XR_935873.3 RNA Sequence

  2. XR_935872.3 RNA Sequence

  3. XR_007067040.1 RNA Sequence

  4. XR_007067043.1 RNA Sequence

    Related
    ENST00000488542.6

  5. XR_007067042.1 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    38041938..38058366 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054322632.1 → XP_054178607.1  dermokine isoform X4

  2. XM_054322633.1 → XP_054178608.1  dermokine isoform X5

  3. XM_054322630.1 → XP_054178605.1  dermokine isoform X3

  4. XM_054322631.1 → XP_054178606.1  dermokine isoform X3

  5. XM_054322629.1 → XP_054178604.1  dermokine isoform X2

  6. XM_054322644.1 → XP_054178619.1  dermokine isoform X14

  7. XM_054322643.1 → XP_054178618.1  dermokine isoform X13

  8. XM_054322640.1 → XP_054178615.1  dermokine isoform X11

  9. XM_054322641.1 → XP_054178616.1  dermokine isoform X11

  10. XM_054322637.1 → XP_054178612.1  dermokine isoform X9

  11. XM_054322638.1 → XP_054178613.1  dermokine isoform X9

  12. XM_054322634.1 → XP_054178609.1  dermokine isoform X6

  13. XM_054322642.1 → XP_054178617.1  dermokine isoform X12

  14. XM_054322636.1 → XP_054178611.1  dermokine isoform X8

  15. XM_054322635.1 → XP_054178610.1  dermokine isoform X7

  16. XM_054322628.1 → XP_054178603.1  dermokine isoform X1

  17. XM_054322639.1 → XP_054178614.1  dermokine isoform X10

  18. XM_054322658.1 → XP_054178633.1  dermokine isoform X26

  19. XM_054322659.1 → XP_054178634.1  dermokine isoform X27

  20. XM_054322657.1 → XP_054178632.1  dermokine isoform X25

  21. XM_054322656.1 → XP_054178631.1  dermokine isoform X24

  22. XM_054322655.1 → XP_054178630.1  dermokine isoform X23

  23. XM_054322653.1 → XP_054178628.1  dermokine isoform X21

  24. XM_054322651.1 → XP_054178626.1  dermokine isoform X20

  25. XM_054322652.1 → XP_054178627.1  dermokine isoform X20

  26. XM_054322648.1 → XP_054178623.1  dermokine isoform X18

  27. XM_054322654.1 → XP_054178629.1  dermokine isoform X22

  28. XM_054322649.1 → XP_054178624.1  dermokine isoform X19

  29. XM_054322650.1 → XP_054178625.1  dermokine isoform X19

  30. XM_054322647.1 → XP_054178622.1  dermokine isoform X17

  31. XM_054322646.1 → XP_054178621.1  dermokine isoform X16

  32. XM_054322645.1 → XP_054178620.1  dermokine isoform X15

RNA

  1. XR_008485219.1 RNA Sequence

  2. XR_008485218.1 RNA Sequence

  3. XR_008485220.1 RNA Sequence

  4. XR_008485222.1 RNA Sequence

  5. XR_008485221.1 RNA Sequence

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6E0U4.3 GenPept UniProtKB/Swiss-Prot:Q6E0U4

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