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CCPG1 cell cycle progression 1 [ Homo sapiens (human) ]

Gene ID: 9236, updated on 27-Nov-2024

Summary

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Official Symbol
CCPG1provided by HGNC
Official Full Name
cell cycle progression 1provided by HGNC
Primary source
HGNC:HGNC:24227
See related
Ensembl:ENSG00000260916 MIM:611326; AllianceGenome:HGNC:24227
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CPR8
Summary
Involved in positive regulation of cell cycle and positive regulation of cell population proliferation. Predicted to be active in membrane. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in thyroid (RPKM 34.7), gall bladder (RPKM 22.2) and 25 other tissues See more
Orthologs
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Genomic context

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See CCPG1 in Genome Data Viewer
Location:
15q21.3
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 15 NC_000015.10 (55355239..55408359, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 15 NC_060939.1 (53158427..53211591, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (55647437..55700557, complement)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9439 Neighboring gene RAB27A, member RAS oncogene family Neighboring gene Sharpr-MPRA regulatory region 6285 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6453 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9440 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9441 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9442 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9443 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9444 Neighboring gene PIGB opposite strand 1 Neighboring gene NANOG hESC enhancer GRCh37_chr15:55644998-55645641 Neighboring gene phosphatidylinositol glycan anchor biosynthesis class B Neighboring gene DNAAF4-CCPG1 readthrough (NMD candidate) Neighboring gene ReSE screen-validated silencer GRCh37_chr15:55674784-55674963 Neighboring gene microRNA 628 Neighboring gene Sharpr-MPRA regulatory region 6559 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9445 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9446 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9447 Neighboring gene piercer of microtubule wall 2 Neighboring gene thioesterase superfamily member 4 pseudogene Neighboring gene dynein axonemal assembly factor 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Clinical and prognostic significance of CCPG1 in hepatocellular carcinoma. Wang G, et al. Gen Physiol Biophys, 2023 Sep. PMID 37702448
  2. RNAi screen indicates widespread biological function for human natural antisense transcripts. Faghihi MA, et al. PLoS One, 2010 Oct 4. PMID 20957177, Free PMC Article
  3. CCPG1 Is a Non-canonical Autophagy Cargo Receptor Essential for ER-Phagy and Pancreatic ER Proteostasis. Smith MD, et al. Dev Cell, 2018 Jan 22. PMID 29290589, Free PMC Article
  4. A genome scale location analysis of human Staf/ZNF143-binding sites suggests a widespread role for human Staf/ZNF143 in mammalian promoters. Myslinski E, et al. J Biol Chem, 2006 Dec 29. PMID 17092945
  5. Human CPR (cell cycle progression restoration) genes impart a Far- phenotype on yeast cells. Edwards MC, et al. Genetics, 1997 Nov. PMID 9383053, Free PMC Article

See all (38) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See Variation Viewer (GRCh37.p13)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Readthrough DNAAF4-CCPG1

Readthrough gene: DNAAF4-CCPG1, Included gene: DNAAF4

Homology

Clone Names

  • FLJ60574, KIAA1254

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in positive regulation of cell cycle IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of cell population proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
cell cycle progression protein 1
Names
cell cycle progression restoration protein 8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001204450.2 → NP_001191379.1  cell cycle progression protein 1 isoform 2

    See identical proteins and their annotated locations for NP_001191379.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks a segment in the 3' coding region that results in a frameshift. The encoded isoform (2) has a distinct and longer C-terminus, compared to isoform 1.
    Source sequence(s)
    AA740595, AC018926, AK292795, DB084778
    Consensus CDS
    CCDS55966.1
    UniProtKB/Swiss-Prot
    Q9ULG6
    Related
    ENSP00000403400.3, ENST00000442196.8
    Conserved Domains (1) summary
    pfam05837
    Location:313 → 401
    CENP-H; Centromere protein H (CENP-H)

  2. NM_001204451.2 → NP_001191380.1  cell cycle progression protein 1 isoform 3

    See identical proteins and their annotated locations for NP_001191380.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks two segments in the 3' coding region, one of which causes a frameshift. The encoded isoform (3) has a distinct C-terminus and is shorter than isoform 1.
    Source sequence(s)
    AA740595, AC018926, AK022459, DB084778
    Consensus CDS
    CCDS55967.1
    UniProtKB/Swiss-Prot
    Q9ULG6
    Related
    ENSP00000415128.3, ENST00000425574.7
    Conserved Domains (2) summary
    PLN02328
    Location:84 → 231
    PLN02328; lysine-specific histone demethylase 1 homolog
    pfam04375
    Location:195 → 321
    HemX; HemX

  3. NM_004748.6 → NP_004739.3  cell cycle progression protein 1 isoform 1

    See identical proteins and their annotated locations for NP_004739.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes isoform 1. Both variants 1 and 2 encode the same isoform.
    Source sequence(s)
    AA740595, AC018926, BC039871, DA670725, DA720583
    Consensus CDS
    CCDS42039.1
    UniProtKB/Swiss-Prot
    A0PJH3, A8K9T0, O14712, Q05DG4, Q5U5S7, Q8IYV8, Q9BY53, Q9HA17, Q9ULG6
    Related
    ENSP00000454456.1, ENST00000569205.5
    Conserved Domains (1) summary
    pfam05837
    Location:313 → 401
    CENP-H; Centromere protein H (CENP-H)

  4. NM_020739.5 → NP_065790.2  cell cycle progression protein 1 isoform 1

    See identical proteins and their annotated locations for NP_065790.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same isoform (1).
    Source sequence(s)
    AA740595, AC018926, BC039871, DB084778
    Consensus CDS
    CCDS42039.1
    UniProtKB/Swiss-Prot
    A0PJH3, A8K9T0, O14712, Q05DG4, Q5U5S7, Q8IYV8, Q9BY53, Q9HA17, Q9ULG6
    Related
    ENSP00000311656.6, ENST00000310958.10
    Conserved Domains (1) summary
    pfam05837
    Location:313 → 401
    CENP-H; Centromere protein H (CENP-H)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p14 Primary Assembly

    Range
    55355239..55408359 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060939.1 Alternate T2T-CHM13v2.0

    Range
    53158427..53211591 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9ULG6.3 GenPept UniProtKB/Swiss-Prot:Q9ULG6

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
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