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LIN52 lin-52 DREAM MuvB core complex component [ Homo sapiens (human) ]

Gene ID: 91750, updated on 27-Nov-2024

Summary

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Official Symbol
LIN52provided by HGNC
Official Full Name
lin-52 DREAM MuvB core complex componentprovided by HGNC
Primary source
HGNC:HGNC:19856
See related
Ensembl:ENSG00000205659 AllianceGenome:HGNC:19856
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
C14orf46; c14_5549
Summary
Predicted to be involved in regulation of DNA-templated transcription. Predicted to be located in nucleoplasm. Predicted to be part of DRM complex. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Low expression observed in reference dataset See more
Orthologs
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Genomic context

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See LIN52 in Genome Data Viewer
Location:
14q24.3
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (74084956..74201493)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (68292638..68409288)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (74551659..74668196)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene ectonucleoside triphosphate diphosphohydrolase 5 (inactive) Neighboring gene Sharpr-MPRA regulatory region 8014 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5924 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5925 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5926 Neighboring gene Sharpr-MPRA regulatory regions 4216 and 10298 Neighboring gene ribosomal protein L41 pseudogene 4 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_36659 Neighboring gene basal body orientation factor 1 Neighboring gene ReSE screen-validated silencer GRCh37_chr14:74530601-74530820 Neighboring gene aldehyde dehydrogenase 6 family member A1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8724 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8725 Neighboring gene uncharacterized LOC105370563 Neighboring gene RNY4 pseudogene 21 Neighboring gene RNA, 7SL, cytoplasmic 530, pseudogene Neighboring gene small ubiquitin-related modifier 2-like Neighboring gene MPRA-validated peak2199 silencer Neighboring gene uncharacterized LOC105370564 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:74707503-74708468 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:74712311-74712812 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5927 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5928 Neighboring gene visual system homeobox 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. A kinase shRNA screen links LATS2 and the pRB tumor suppressor. Tschöp K, et al. Genes Dev, 2011 Apr 15. PMID 21498571, Free PMC Article
  2. DYRK1A protein kinase promotes quiescence and senescence through DREAM complex assembly. Litovchick L, et al. Genes Dev, 2011 Apr 15. PMID 21498570, Free PMC Article
  3. The cell cycle regulatory DREAM complex is disrupted by high expression of oncogenic B-Myb. Iness AN, et al. Oncogene, 2019 Feb. PMID 30206359, Free PMC Article
  4. Structural mechanisms of DREAM complex assembly and regulation. Guiley KZ, et al. Genes Dev, 2015 May 1. PMID 25917549, Free PMC Article
  5. LINC, a human complex that is related to pRB-containing complexes in invertebrates regulates the expression of G2/M genes. Schmit F, et al. Cell Cycle, 2007 Aug 1. PMID 17671431

See all (34) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
    Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Submit: New GeneRIF Correction

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Web-based, participant-driven studies yield novel genetic associations for common traits.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of DRM complex IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm TAS
Traceable Author Statement
more info
  

General protein information

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Preferred Names
protein lin-52 homolog
Names
lin-52 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001024674.3 → NP_001019845.2  protein lin-52 homolog isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC006349, AK023979, BC094003
    Consensus CDS
    CCDS32120.2
    UniProtKB/TrEMBL
    B3KN83
    Related
    ENSP00000451812.2, ENST00000555028.7
    Conserved Domains (1) summary
    pfam10044
    Location:14 → 107
    LIN52; Retinal tissue protein

  2. NM_001372005.1 → NP_001358934.1  protein lin-52 homolog isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC005484
    Conserved Domains (1) summary
    pfam10044
    Location:14 → 94
    LIN52; Retinal tissue protein

  3. NM_001372006.1 → NP_001358935.1  protein lin-52 homolog isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC005484, AC006349
    Conserved Domains (1) summary
    pfam10044
    Location:12 → 105
    LIN52; Retinal tissue protein

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

    Range
    74084956..74201493
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017021764.2 → XP_016877253.1  protein lin-52 homolog isoform X6

    Conserved Domains (1) summary
    pfam10044
    Location:18 → 98
    LIN52; Retinal tissue protein

  2. XM_047431916.1 → XP_047287872.1  protein lin-52 homolog isoform X1

  3. XM_011537321.4 → XP_011535623.2  protein lin-52 homolog isoform X2

  4. XM_047431917.1 → XP_047287873.1  protein lin-52 homolog isoform X3

  5. XM_011537322.3 → XP_011535624.2  protein lin-52 homolog isoform X4

  6. XM_047431918.1 → XP_047287874.1  protein lin-52 homolog isoform X5

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060938.1 Alternate T2T-CHM13v2.0

    Range
    68292638..68409288
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054376977.1 → XP_054232952.1  protein lin-52 homolog isoform X6

  2. XM_054376972.1 → XP_054232947.1  protein lin-52 homolog isoform X1

  3. XM_054376973.1 → XP_054232948.1  protein lin-52 homolog isoform X2

  4. XM_054376974.1 → XP_054232949.1  protein lin-52 homolog isoform X3

  5. XM_054376975.1 → XP_054232950.1  protein lin-52 homolog isoform X4

  6. XM_054376976.1 → XP_054232951.1  protein lin-52 homolog isoform X5

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q52LA3.1 GenPept UniProtKB/Swiss-Prot:Q52LA3

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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