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Sh2b1 SH2B adaptor protein 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 89817, updated on 4-Jan-2025

Summary

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Official Symbol
Sh2b1provided by RGD
Official Full Name
SH2B adaptor protein 1provided by RGD
Primary source
RGD:620132
See related
EnsemblRapid:ENSRNOG00000049181 AllianceGenome:RGD:620132
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Sh2b; Sh2-b; Sh2bpsm1
Summary
Predicted to enable transmembrane receptor protein tyrosine kinase adaptor activity. Predicted to be involved in intracellular signal transduction; positive regulation of mitotic nuclear division; and regulation of DNA biosynthetic process. Predicted to act upstream of or within cell motility; lamellipodium assembly; and positive regulation of SMAD protein signal transduction. Predicted to be located in cytoplasm and nucleus. Predicted to be active in plasma membrane. Orthologous to human SH2B1 (SH2B adaptor protein 1). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Thymus (RPKM 65.5), Kidney (RPKM 60.5) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Sh2b1 in Genome Data Viewer
Location:
1q36
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (190479211..190492030, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (181048622..181057036, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (197878839..197888223, complement)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene CD19 molecule Neighboring gene rabaptin, RAB GTPase binding effector protein 2 Neighboring gene ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1 Neighboring gene Tu translation elongation factor, mitochondrial Neighboring gene uncharacterized LOC134483838 Neighboring gene ataxin 2-like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. SH2B1 protects against OGD/R‑induced apoptosis in PC12 cells via activation of the JAK2/STAT3 signaling pathway. Yuan J, et al. Mol Med Rep, 2018 Sep. PMID 30015896, Free PMC Article
  2. The yeast tribrid system--genetic detection of trans-phosphorylated ITAM-SH2-interactions. Osborne MA, et al. Biotechnology (N Y), 1995 Dec. PMID 9636306
  3. New function of the adaptor protein SH2B1 in brain-derived neurotrophic factor-induced neurite outgrowth. Shih CH, et al. PLoS One, 2013. PMID 24260264, Free PMC Article
  4. Adapter protein SH2-B beta undergoes nucleocytoplasmic shuttling: implications for nerve growth factor induction of neuronal differentiation. Chen L, et al. Mol Cell Biol, 2004 May. PMID 15082760, Free PMC Article
  5. SH2B1beta (SH2-Bbeta) enhances expression of a subset of nerve growth factor-regulated genes important for neuronal differentiation including genes encoding urokinase plasminogen activator receptor and matrix metalloproteinase 3/10. Chen L, et al. Mol Endocrinol, 2008 Feb. PMID 17947375, Free PMC Article

See all (27) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. miR-14 2-3 p not only mitigate cardiac hypertrophy by directly inhibit the expression of gene SH2B1, but also can protect mitochondrial function in cardiac hypertrophy of vitro and vivo.
    Title: Overexpression of miR-142-3p improves mitochondrial function in cardiac hypertrophy.
  2. SH2B1 overexpression resulted in increased viability, reduced lactate dehydrogenase release and a reduction in the expression levels of proteins associated with the apoptotic cascade in PC12 cells under the oxygenglucose deprivation condition.
    Title: SH2B1 protects against OGD/R‑induced apoptosis in PC12 cells via activation of the JAK2/STAT3 signaling pathway.
  3. These findings suggest that SH2B1-IRSp53 complexes promote the formation of filopodia, neurite initiation, and neuronal branching.
    Title: SH2B1 and IRSp53 proteins promote the formation of dendrites and dendritic branches.
  4. findings demonstrate that SH2B1beta promotes BDNF-induced neurite outgrowth through enhancing pathways involved MEK-ERK1/2 and PI3K-AKT.
    Title: New function of the adaptor protein SH2B1 in brain-derived neurotrophic factor-induced neurite outgrowth.
  5. Long-Evans rats maintained on chow or a high-fat diet (HFD) for 6 weeks. From a total of 19 genes analyzed, seven genes (ETV5, FTO, GNPDA2, KCTD15, TMEM18, MC4R, and SH2B1) were down-regulated in the hypothalamus of HFD compared to chow-fed rats
    Title: Expression of new loci associated with obesity in diet-induced obese rats: from genetics to physiology.
  6. These findings provide significant new insights into how N-cadherin-mediated inter-cellular interactions may influence neurite initiation and how SH2B1beta may regulate these processes.
    Title: SH2B1β regulates N-cadherin levels, cell-cell adhesion and nerve growth factor-induced neurite initiation.
  7. SH2B1beta must shuttle between the plasma membrane and nucleus to function as a critical component of NGF-induced gene expression and neuronal differentiation.
    Title: Nucleocytoplasmic shuttling of the adapter protein SH2B1beta (SH2-Bbeta) is required for nerve growth factor (NGF)-dependent neurite outgrowth and enhancement of expression of a subset of NGF-responsive genes.
  8. SH2B1beta enhances FGF1-induced neurite outgrowth in PC12 cells mainly through MEK-ERK1/2-STAT3-Egr1 pathway.
    Title: SH2B1beta enhances fibroblast growth factor 1 (FGF1)-induced neurite outgrowth through MEK-ERK1/2-STAT3-Egr1 pathway.
  9. Results suggest that SH2B1beta stimulates NGF-induced neuronal differentiation at least in part by enhancing expression of a specific subset of NGF-sensitive genes, including Plaur, Mmp3, and/or Mmp10, required for neurite outgrowth.
    Title: SH2B1beta (SH2-Bbeta) enhances expression of a subset of nerve growth factor-regulated genes important for neuronal differentiation including genes encoding urokinase plasminogen activator receptor and matrix metalloproteinase 3/10.
  10. SH2-Bbeta and APS do not activate JAK2 as a consequence of their own dimerization, recruitment of an activator of JAK2, or direct competition with a JAK2 inhibitor for binding to JAK2. They most likely induce or stabilize an active conformation of JAK2.
    Title: Binding of SH2-B family members within a potential negative regulatory region maintains JAK2 in an active state.
Submit: New GeneRIF Correction See all GeneRIFs (12)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables signaling adaptor activity IEA
Inferred from Electronic Annotation
more info
  
enables transmembrane receptor protein tyrosine kinase adaptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in cell motility IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cell motility ISO
Inferred from Sequence Orthology
more info
  
involved_in cell surface receptor protein tyrosine kinase signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in lamellipodium assembly IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within lamellipodium assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of SMAD protein signal transduction IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within positive regulation of SMAD protein signal transduction ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of mitotic nuclear division IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of mitotic nuclear division ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of DNA biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of DNA biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
SH2B adapter protein 1
Names
SH2 domain-containing protein 1B
SH2-B PH domain-containing signaling mediator 1
fceRI gamma-chain-interacting protein SH2-B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001048180.1 → NP_001041645.1  SH2B adapter protein 1 isoform 2

    See identical proteins and their annotated locations for NP_001041645.1

    Status: VALIDATED

    Source sequence(s)
    AAHX01008496, AF047577, AI029537, BM389529, U57391
    UniProtKB/TrEMBL
    A0A8L2QYJ5, A6I967
    Conserved Domains (3) summary
    cd10346
    Location:518 → 614
    SH2_SH2B_family; Src homology 2 (SH2) domain found in SH2B adapter protein family
    cd01231
    Location:247 → 378
    PH_SH2B_family; SH2B adapter protein 1, 2, and 3 Pleckstrin homology (PH) domain
    pfam08916
    Location:26 → 81
    Phe_ZIP; Phenylalanine zipper

  2. NM_134456.3 → NP_604451.2  SH2B adapter protein 1 isoform 1

    See identical proteins and their annotated locations for NP_604451.2

    Status: VALIDATED

    Source sequence(s)
    AF047577, AI029537, BM389529, CB742512, U57391
    UniProtKB/Swiss-Prot
    O55072, Q62985
    UniProtKB/TrEMBL
    A0A8L2QYJ5, A6I961
    Conserved Domains (4) summary
    cd10346
    Location:518 → 614
    SH2_SH2B_family; Src homology 2 (SH2) domain found in SH2B adapter protein family
    cd01231
    Location:247 → 378
    PH_SH2B_family; SH2B adapter protein 1, 2, and 3 Pleckstrin homology (PH) domain
    pfam00169
    Location:312 → 376
    PH; PH domain
    pfam08916
    Location:26 → 81
    Phe_ZIP; Phenylalanine zipper

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    190479211..190492030 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006230354.5 → XP_006230416.1  SH2B adapter protein 1 isoform X1

    See identical proteins and their annotated locations for XP_006230416.1

    UniProtKB/Swiss-Prot
    O55072, Q62985
    UniProtKB/TrEMBL
    A0A8L2QYJ5, A6I961
    Conserved Domains (4) summary
    cd10346
    Location:518 → 614
    SH2_SH2B_family; Src homology 2 (SH2) domain found in SH2B adapter protein family
    cd01231
    Location:247 → 378
    PH_SH2B_family; SH2B adapter protein 1, 2, and 3 Pleckstrin homology (PH) domain
    pfam00169
    Location:312 → 376
    PH; PH domain
    pfam08916
    Location:26 → 81
    Phe_ZIP; Phenylalanine zipper

  2. XM_063276001.1 → XP_063132071.1  SH2B adapter protein 1 isoform X4

    UniProtKB/TrEMBL
    A0A8L2QYJ5, A6I967

  3. XM_063275992.1 → XP_063132062.1  SH2B adapter protein 1 isoform X2

    UniProtKB/TrEMBL
    A6I963, M0R617

  4. XM_063275999.1 → XP_063132069.1  SH2B adapter protein 1 isoform X3

    UniProtKB/TrEMBL
    A0A8L2QYJ5, A6I970

  5. XM_063275993.1 → XP_063132063.1  SH2B adapter protein 1 isoform X3

    UniProtKB/TrEMBL
    A0A8L2QYJ5, A6I970

  6. XM_063275991.1 → XP_063132061.1  SH2B adapter protein 1 isoform X2

    UniProtKB/TrEMBL
    A6I963, M0R617

  7. XM_039093107.2 → XP_038949035.1  SH2B adapter protein 1 isoform X2

    UniProtKB/TrEMBL
    A6I963, M0R617
    Related
    ENSRNOP00000066048.3, ENSRNOT00000074274.4
    Conserved Domains (3) summary
    cd10346
    Location:518 → 614
    SH2_SH2B_family; Src homology 2 (SH2) domain found in SH2B adapter protein family
    cd01231
    Location:247 → 378
    PH_SH2B_family; SH2B adapter protein 1, 2, and 3 Pleckstrin homology (PH) domain
    pfam08916
    Location:26 → 81
    Phe_ZIP; Phenylalanine zipper

  8. XM_039093117.2 → XP_038949045.1  SH2B adapter protein 1 isoform X3

    UniProtKB/TrEMBL
    A0A8L2QYJ5, A6I970
    Related
    ENSRNOP00000064854.3, ENSRNOT00000071241.5
    Conserved Domains (3) summary
    cd10346
    Location:518 → 614
    SH2_SH2B_family; Src homology 2 (SH2) domain found in SH2B adapter protein family
    cd01231
    Location:247 → 378
    PH_SH2B_family; SH2B adapter protein 1, 2, and 3 Pleckstrin homology (PH) domain
    pfam08916
    Location:26 → 81
    Phe_ZIP; Phenylalanine zipper

  9. XM_006230353.5 → XP_006230415.1  SH2B adapter protein 1 isoform X1

    See identical proteins and their annotated locations for XP_006230415.1

    UniProtKB/Swiss-Prot
    O55072, Q62985
    UniProtKB/TrEMBL
    A0A8L2QYJ5, A6I961
    Conserved Domains (4) summary
    cd10346
    Location:518 → 614
    SH2_SH2B_family; Src homology 2 (SH2) domain found in SH2B adapter protein family
    cd01231
    Location:247 → 378
    PH_SH2B_family; SH2B adapter protein 1, 2, and 3 Pleckstrin homology (PH) domain
    pfam00169
    Location:312 → 376
    PH; PH domain
    pfam08916
    Location:26 → 81
    Phe_ZIP; Phenylalanine zipper

  10. XM_063276000.1 → XP_063132070.1  SH2B adapter protein 1 isoform X4

    UniProtKB/TrEMBL
    A0A8L2QYJ5, A6I967

  11. XM_039093126.2 → XP_038949054.1  SH2B adapter protein 1 isoform X4

    UniProtKB/TrEMBL
    A0A8L2QYJ5, A6I967
    Conserved Domains (3) summary
    cd10346
    Location:518 → 614
    SH2_SH2B_family; Src homology 2 (SH2) domain found in SH2B adapter protein family
    cd01231
    Location:247 → 378
    PH_SH2B_family; SH2B adapter protein 1, 2, and 3 Pleckstrin homology (PH) domain
    pfam08916
    Location:26 → 81
    Phe_ZIP; Phenylalanine zipper

RNA

  1. XR_005493701.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q62985.1 GenPept UniProtKB/Swiss-Prot:Q62985

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