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pks1 polyketide synthase [ Mycobacterium tuberculosis H37Rv ]

Gene ID: 888122, updated on 6-Oct-2023

Summary

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Gene symbol
pks1
Gene description
polyketide synthase
Locus tag
Rv2946c
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mycobacterium tuberculosis H37Rv (strain: H37Rv, type-material: type strain of Mycobacterium tuberculosis)
Lineage
Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex
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Genomic context

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Sequence:
NC_000962.3 (3291503..3296353, complement)

NC_000962.3Genomic Context describing neighboring genes Neighboring gene transposase Neighboring gene insertion sequence element IS1533 transposase Neighboring gene lipoprotein LppX Neighboring gene polyketide synthase Neighboring gene p-hydroxybenzoyl--AMP ligase Neighboring gene chorismate pyruvate-lyase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000962.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Acyl-CoA carboxylases (accD2 and accD3), together with a unique polyketide synthase (Cg-pks), are key to mycolic acid biosynthesis in Corynebacterianeae such as Corynebacterium glutamicum and Mycobacterium tuberculosis. Gande R, et al. J Biol Chem, 2004 Oct 22. PMID 15308633
  2. TubercuList--10 years after. Lew JM, et al. Tuberculosis (Edinb), 2011 Jan. PMID 20980199
  3. Re-annotation of the genome sequence of Mycobacterium tuberculosis H37Rv. Camus JC, et al. Microbiology (Reading), 2002 Oct. PMID 12368430
  4. Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence. Cole ST, et al. Nature, 1998 Jun 11. PMID 9634230

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Acyl-CoA carboxylases (accD2 and accD3), together with a unique polyketide synthase (Cg-pks), have key roles in mycolic acid biosynthesis in Corynebacterianeae
    Title: Acyl-CoA carboxylases (accD2 and accD3), together with a unique polyketide synthase (Cg-pks), are key to mycolic acid biosynthesis in Corynebacterianeae such as Corynebacterium glutamicum and Mycobacterium tuberculosis.
Submit: New GeneRIF Correction

General gene information

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Homology

General protein information

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Preferred Names
polyketide synthase

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000962.3 Reference assembly

    Range
    3291503..3296353 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_217462.1 polyketide synthase [Mycobacterium tuberculosis H37Rv]

    See identical proteins and their annotated locations for NP_217462.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    F2GL66, Q7D6E1
    Conserved Domains (5) summary
    cd08956
    Location:1227 → 1484
    KR_3_FAS_SDR_x; beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x)
    smart00823
    Location:1504 → 1588
    PKS_PP; Phosphopantetheine attachment site
    smart00829
    Location:942 → 1215
    PKS_ER; Enoylreductase
    COG3321
    Location:1 → 642
    PksD; Acyl transferase domain in polyketide synthase (PKS) enzymes [Secondary metabolites biosynthesis, transport and catabolism]
    cl21454
    Location:732 → 912
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P96285.4

Gene LinkOut

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Molecular Biology Databases