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pks11 chalcone synthase [ Mycobacterium tuberculosis H37Rv ]

Gene ID: 885525, updated on 6-Oct-2023

Summary

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Gene symbol
pks11
Gene description
chalcone synthase
Locus tag
Rv1665
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mycobacterium tuberculosis H37Rv (strain: H37Rv, type-material: type strain of Mycobacterium tuberculosis)
Lineage
Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex
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Genomic context

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Sequence:
NC_000962.3 (1891226..1892287)

NC_000962.3Genomic Context describing neighboring genes Neighboring gene polyketide synthase Neighboring gene polyketide synthase Neighboring gene polyketide synthase Neighboring gene cytochrome P450 Cyp139 Neighboring gene pseudo Neighboring gene hypothetical protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000962.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Crystal structure of Mycobacterium tuberculosis polyketide synthase 11 (PKS11) reveals intermediates in the synthesis of methyl-branched alkylpyrones. Gokulan K, et al. J Biol Chem, 2013 Jun 7. PMID 23615910, Free PMC Article
  2. TubercuList--10 years after. Lew JM, et al. Tuberculosis (Edinb), 2011 Jan. PMID 20980199
  3. Re-annotation of the genome sequence of Mycobacterium tuberculosis H37Rv. Camus JC, et al. Microbiology (Reading), 2002 Oct. PMID 12368430
  4. Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence. Cole ST, et al. Nature, 1998 Jun 11. PMID 9634230

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. PKS11 has a deep hydrophobic tunnel proximal to the active site Cys-138 to accommodate substrates.
    Title: Crystal structure of Mycobacterium tuberculosis polyketide synthase 11 (PKS11) reveals intermediates in the synthesis of methyl-branched alkylpyrones.
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General gene information

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Homology

General protein information

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Preferred Names
chalcone synthase

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000962.3 Reference assembly

    Range
    1891226..1892287
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_216181.1 chalcone synthase [Mycobacterium tuberculosis H37Rv]

    See identical proteins and their annotated locations for NP_216181.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A654TW62
    Conserved Domains (1) summary
    COG3424
    Location:1 → 353
    BH0617; Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport and catabolism]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P9WPF3.1

Gene LinkOut

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Molecular Biology Databases