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espA ESX-1 secretion-associated protein EspA [ Mycobacterium tuberculosis H37Rv ]

Gene ID: 885377, updated on 17-Apr-2021

Summary

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Gene symbol
espA
Gene description
ESX-1 secretion-associated protein EspA
Locus tag
Rv3616c
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mycobacterium tuberculosis H37Rv (strain: H37Rv, type-material: type strain of Mycobacterium tuberculosis)
Lineage
Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex
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Genomic context

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Sequence:
NC_000962.3 (4055197..4056375, complement)

NC_000962.3Genomic Context describing neighboring genes Neighboring gene ESX-1 secretion-associated protein EspD Neighboring gene ESX-1 secretion-associated protein EspC Neighboring gene epoxide hydrolase EphA Neighboring gene monooxygenase Neighboring gene ESAT-6 like protein EsxV

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000962.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Phenotypic profiling of Mycobacterium tuberculosis EspA point mutants reveals that blockage of ESAT-6 and CFP-10 secretion in vitro does not always correlate with attenuation of virulence. Chen JM, et al. J Bacteriol, 2013 Dec. PMID 24078612, Free PMC Article
  2. TubercuList--10 years after. Lew JM, et al. Tuberculosis (Edinb), 2011 Jan. PMID 20980199
  3. Re-annotation of the genome sequence of Mycobacterium tuberculosis H37Rv. Camus JC, et al. Microbiology (Reading), 2002 Oct. PMID 12368430
  4. Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence. Cole ST, et al. Nature, 1998 Jun 11. PMID 9634230

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Authors identified amino acid residues in EspA that are important for facilitating ESAT-6 and CFP-10 secretion and virulence.
    Title: Phenotypic profiling of Mycobacterium tuberculosis EspA point mutants reveals that blockage of ESAT-6 and CFP-10 secretion in vitro does not always correlate with attenuation of virulence.
Submit: New GeneRIF Correction

General gene information

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Homology

General protein information

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Preferred Names
ESX-1 secretion-associated protein EspA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000962.3 Reference assembly

    Range
    4055197..4056375 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_218133.1 ESX-1 secretion-associated protein EspA [Mycobacterium tuberculosis H37Rv]

    See identical proteins and their annotated locations for NP_218133.1

    Status: PROVISIONAL

    Conserved Domains (1) summary
    pfam18879
    Location:21 → 104
    EspA_EspE; EspA/EspE family
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P9WJE1.1

Gene LinkOut

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Molecular Biology Databases