U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

mscL large-conductance ion mechanosensitive channel [ Mycobacterium tuberculosis H37Rv ]

Gene ID: 885368, updated on 6-Aug-2024

Summary

Go to the top of the page Help
Gene symbol
mscL
Gene description
large-conductance ion mechanosensitive channel
Locus tag
Rv0985c
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mycobacterium tuberculosis H37Rv (strain: H37Rv, type-material: type strain of Mycobacterium tuberculosis)
Lineage
Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Sequence:
NC_000962.3 (1101025..1101480, complement)

NC_000962.3Genomic Context describing neighboring genes Neighboring gene two-component response regulator MrpA Neighboring gene two component histidine-protein kinase/phosphatase MprB Neighboring gene serine protease PepD Neighboring gene pterin-4-alpha-carbinolamine dehydratase Neighboring gene adhesion component ABC transporter ATP-binding protein Neighboring gene adhesion component ABC transporter permease Neighboring gene hypothetical protein

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_000962.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Force transduction and lipid binding in MscL: a continuum-molecular approach. Vanegas JM, et al. PLoS One, 2014. PMID 25437007, Free PMC Article
  2. Heterogeneity in the binding of lipid molecules to the surface of a membrane protein: hot spots for anionic lipids on the mechanosensitive channel of large conductance MscL and effects on conformation. Powl AM, et al. Biochemistry, 2005 Apr 19. PMID 15823046
  3. Identification of the hydrophobic thickness of a membrane protein using fluorescence spectroscopy: studies with the mechanosensitive channel MscL. Powl AM, et al. Biochemistry, 2005 Apr 19. PMID 15823029
  4. Conversion of a mechanosensitive channel protein from a membrane-embedded to a water-soluble form by covalent modification with amphiphiles. Becker CF, et al. J Mol Biol, 2004 Oct 22. PMID 15465059
  5. Cysteine scanning of MscL transmembrane domains reveals residues critical for mechanosensitive channel gating. Levin G, et al. Biophys J, 2004 May. PMID 15111403, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Results show the interaction of lipids with MscL using atomistic molecular dynamics simulations and identify the simple motif that confers MscL with strong anchoring to the bilayer.
    Title: Force transduction and lipid binding in MscL: a continuum-molecular approach.
  2. binding site of high affinity for anionic phospholipids
    Title: Heterogeneity in the binding of lipid molecules to the surface of a membrane protein: hot spots for anionic lipids on the mechanosensitive channel of large conductance MscL and effects on conformation.
  3. very efficient hydrophobic matching between the protein and the surrounding lipid bilayer
    Title: Identification of the hydrophobic thickness of a membrane protein using fluorescence spectroscopy: studies with the mechanosensitive channel MscL.
  4. residues in the primary gate in the first transmembrane domain of MscL are critical for mechanosensitive channel gating
    Title: Cysteine scanning of MscL transmembrane domains reveals residues critical for mechanosensitive channel gating.
  5. Data show that solubilization of membrane proteins such as the MscL by covalent attachment of amphiphiles results in homogeneous particles that may prove useful for crystallization, solution NMR spectroscopy, and electron microscopy.
    Title: Conversion of a mechanosensitive channel protein from a membrane-embedded to a water-soluble form by covalent modification with amphiphiles.
Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Homology

General protein information

Go to the top of the page Help
Preferred Names
large-conductance ion mechanosensitive channel

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000962.3 Reference assembly

    Range
    1101025..1101480 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_215500.1 large-conductance ion mechanosensitive channel [Mycobacterium tuberculosis H37Rv]

    See identical proteins and their annotated locations for NP_215500.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    R4M0G1
    Conserved Domains (1) summary
    PRK00567
    Location:1 → 125
    mscL; large-conductance mechanosensitive channel protein MscL
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P9WJN5.1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Other Literature Sources
Molecular Biology Databases
Research Materials