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pknE serine/threonine-protein kinase PknE [ Mycobacterium tuberculosis H37Rv ]

Gene ID: 885284, updated on 11-Dec-2020

Summary

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Gene symbol
pknE
Gene description
serine/threonine-protein kinase PknE
Locus tag
Rv1743
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mycobacterium tuberculosis H37Rv (strain: H37Rv, type-material: type strain of Mycobacterium tuberculosis)
Lineage
Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex
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Genomic context

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Sequence:
NC_000962.3 (1969004..1970704)

NC_000962.3Genomic Context describing neighboring genes Neighboring gene antitoxin VapB34 Neighboring gene ribonuclease VapC34 Neighboring gene hypothetical protein Neighboring gene membrane protein Neighboring gene isopentenyl-diphosphate delta-isomerase Neighboring gene serine/threonine-protein kinase PknF

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000962.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Proteome and phosphoproteome analysis of the serine/threonine protein kinase E mutant of Mycobacterium tuberculosis. Parandhaman DK, et al. Life Sci, 2014 Jul 30. PMID 24972353
  2. Protein kinase E of Mycobacterium tuberculosis has a role in the nitric oxide stress response and apoptosis in a human macrophage model of infection. Jayakumar D, et al. Cell Microbiol, 2008 Feb. PMID 17892498
  3. A conserved dimer and global conformational changes in the structure of apo-PknE Ser/Thr protein kinase from Mycobacterium tuberculosis. Gay LM, et al. J Mol Biol, 2006 Jul 7. PMID 16762364
  4. TubercuList--10 years after. Lew JM, et al. Tuberculosis (Edinb), 2011 Jan. PMID 20980199
  5. Re-annotation of the genome sequence of Mycobacterium tuberculosis H37Rv. Camus JC, et al. Microbiology (Reading), 2002 Oct. PMID 12368430

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Proteome and phosphoproteome data decipher the function of PknE in cell division, virulence, dormancy, suppression of sigma factor B and its regulated genes, suppression of two-component systems and in the metabolic activity of M. tuberculosis.
    Title: Proteome and phosphoproteome analysis of the serine/threonine protein kinase E mutant of Mycobacterium tuberculosis.
  2. PknE senses nitric oxide stress and prevents apoptosis by interfering with host signalling pathways.
    Title: Protein kinase E of Mycobacterium tuberculosis has a role in the nitric oxide stress response and apoptosis in a human macrophage model of infection.
  3. The PknE Kinase Domain formed a dimer. This structure may represent an inactive conformation stabilized by dimerization or, an active conformation that reveals shifts that mediate nucleotide exchange and order substrate binding.
    Title: A conserved dimer and global conformational changes in the structure of apo-PknE Ser/Thr protein kinase from Mycobacterium tuberculosis.
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General gene information

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Homology

General protein information

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Preferred Names
serine/threonine-protein kinase PknE

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000962.3 Reference assembly

    Range
    1969004..1970704
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_216259.1 serine/threonine-protein kinase PknE [Mycobacterium tuberculosis H37Rv]

    See identical proteins and their annotated locations for NP_216259.1

    Status: PROVISIONAL

    Conserved Domains (2) summary
    COG1651
    Location:383 → 566
    DsbG; Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]
    cd14014
    Location:15 → 267
    STKc_PknB_like; Catalytic domain of bacterial Serine/Threonine kinases, PknB and similar proteins
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P9WI77.1

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