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wbpE UDP-2-acetamido-2-deoxy-3-oxo-D-glucuronate aminotransferase [ Pseudomonas aeruginosa PAO1 ]

Gene ID: 882653, updated on 11-Sep-2024

Summary

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Gene symbol
wbpE
Gene description
UDP-2-acetamido-2-deoxy-3-oxo-D-glucuronate aminotransferase
Locus tag
PA3155
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Pseudomonas aeruginosa PAO1 (strain: PAO1)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Pseudomonadales; Pseudomonadaceae; Pseudomonas
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Genomic context

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Sequence:
NC_002516.2 (3539128..3540207, complement)

NC_002516.2Genomic Context describing neighboring genes Neighboring gene imidazole glycerol phosphate synthase subunit HisF Neighboring gene imidazole glycerol phosphate synthase subunit HisH Neighboring gene O-antigen translocase Neighboring gene B-band O-antigen polymerase Neighboring gene UDP-2-acetamido-3-amino-2,3-dideoxy-D-glucuronate N-acetyltransferase Neighboring gene acetyltransferase Neighboring gene UDP-N-acetyl-2-amino-2-deoxy-D-glucuronate oxidase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_002516.2

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Structural analysis of WbpE from Pseudomonas aeruginosa PAO1: a nucleotide sugar aminotransferase involved in O-antigen assembly. Larkin A, et al. Biochemistry, 2010 Aug 24. PMID 20604544, Free PMC Article
  2. Biosynthesis of a rare di-N-acetylated sugar in the lipopolysaccharides of both Pseudomonas aeruginosa and Bordetella pertussis occurs via an identical scheme despite different gene clusters. Westman EL, et al. J Bacteriol, 2008 Sep. PMID 18621892, Free PMC Article
  3. Biosynthesis of UDP-GlcNAc(3NAc)A by WbpB, WbpE, and WbpD: enzymes in the Wbp pathway responsible for O-antigen assembly in Pseudomonas aeruginosa PAO1. Larkin A, et al. Biochemistry, 2009 Jun 16. PMID 19348502, Free PMC Article
  4. Characterization of WbpB, WbpE, and WbpD and reconstitution of a pathway for the biosynthesis of UDP-2,3-diacetamido-2,3-dideoxy-D-mannuronic acid in Pseudomonas aeruginosa. Westman EL, et al. J Biol Chem, 2009 May 1. PMID 19282284, Free PMC Article
  5. Pseudomonas Genome Database: facilitating user-friendly, comprehensive comparisons of microbial genomes. Winsor GL, et al. Nucleic Acids Res, 2009 Jan. PMID 18978025, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Presented is crystal structure of the aminotransferase WbpE from P. aeruginosa PAO1 in complex with the cofactor pyridoxal 5'-phosphate (PLP) and product UDP-GlcNAc(3NH(2))A as the external aldimine at 1.9 A resolution.
    Title: Structural analysis of WbpE from Pseudomonas aeruginosa PAO1: a nucleotide sugar aminotransferase involved in O-antigen assembly.
  2. Biosynthesis of UDP-GlcNAc(3NAc)A by WbpE enzyme in the Wbp pathway responsible for O-antigen assembly in Pseudomonas aeruginosa PAO1
    Title: Biosynthesis of UDP-GlcNAc(3NAc)A by WbpB, WbpE, and WbpD: enzymes in the Wbp pathway responsible for O-antigen assembly in Pseudomonas aeruginosa PAO1.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by PseudoCAP

Function Evidence Code Pubs
enables transaminase activity EXP
Inferred from Experiment
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within O antigen biosynthetic process EXP
Inferred from Experiment
more info
 PubMed 
acts_upstream_of_or_within UDP-glucuronate biosynthetic process EXP
Inferred from Experiment
more info
 PubMed 
acts_upstream_of_or_within polysaccharide biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
UDP-2-acetamido-2-deoxy-3-oxo-D-glucuronate aminotransferase
NP_251845.1
  • Product name confidence: class 1: Function experimentally demonstrated in P. aeruginosa

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_002516.2 Reference assembly

    Range
    3539128..3540207 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_251845.1 UDP-2-acetamido-2-deoxy-3-oxo-D-glucuronate aminotransferase [Pseudomonas aeruginosa PAO1]

    See identical proteins and their annotated locations for NP_251845.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    Q9HZ76
    Conserved Domains (1) summary
    COG0399
    Location:2 → 359
    WecE; dTDP-4-amino-4,6-dideoxygalactose transaminase [Cell wall/membrane/envelope biogenesis]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9HZ76.1

Gene LinkOut

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Molecular Biology Databases
Research Materials