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mutL DNA mismatch repair protein [ Pseudomonas aeruginosa PAO1 ]

Gene ID: 878468, updated on 24-Aug-2024

Summary

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Gene symbol
mutL
Gene description
DNA mismatch repair protein
Locus tag
PA4946
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Pseudomonas aeruginosa PAO1 (strain: PAO1)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Pseudomonadales; Pseudomonadaceae; Pseudomonas
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Genomic context

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Sequence:
NC_002516.2 (5549780..5551681, complement)

NC_002516.2Genomic Context describing neighboring genes Neighboring gene RNA-binding protein Hfq Neighboring gene tRNA delta(2)-isopentenylpyrophosphate transferase Neighboring gene N-acetylmuramoyl-L-alanine amidase Neighboring gene hypothetical protein Neighboring gene hypothetical protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_002516.2

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Analysis of DNA structure and sequence requirements for Pseudomonas aeruginosa MutL endonuclease activity. Correa EM, et al. J Biochem, 2013 Dec. PMID 23969026
  2. The mutL mutation in Pseudomonas aeruginosa isolates reveals multidrug-resistant traits and possible evolutionary trends. Wang YM, et al. J Int Med Res, 2010. PMID 21227005
  3. Some amino acids of the Pseudomonas aeruginosa MutL D(Q/M)HA(X)(2)E(X)(4)E conserved motif are essential for the in vivo function of the protein but not for the in vitro endonuclease activity. Correa EM, et al. DNA Repair (Amst), 2011 Nov 10. PMID 21889424
  4. In vitro and in vivo studies of MutS, MutL and MutH mutants: correlation of mismatch repair and DNA recombination. Junop MS, et al. DNA Repair (Amst), 2003 Apr 2. PMID 12606120
  5. DNA mismatch correction in a defined system. Lahue RS, et al. Science, 1989 Jul 14. PMID 2665076

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The results showed that PaMutL was able to nick covalently closed circular plasmids but not linear DNA at high ionic strengths, while the activity on linear DNA was only found below 60 mM salt.
    Title: Analysis of DNA structure and sequence requirements for Pseudomonas aeruginosa MutL endonuclease activity.
  2. Some amino acids of the Pseudomonas aeruginosa MutL D(Q/M)HA(X)(2)E(X)(4)E conserved motif are essential for the in vivo function of the protein but not for the in vitro endonuclease activity.
    Title: Some amino acids of the Pseudomonas aeruginosa MutL D(Q/M)HA(X)(2)E(X)(4)E conserved motif are essential for the in vivo function of the protein but not for the in vitro endonuclease activity.
  3. multidrug-resistant (MDR)characteristics and PFGE profiles were clearly correlated with the mutL phylogenetic tree; this indicates that mutations in mutL might contribute to genetic stability in adaptation by changing the MDR traits
    Title: The mutL mutation in Pseudomonas aeruginosa isolates reveals multidrug-resistant traits and possible evolutionary trends.
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General gene information

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Homology

Gene Ontology Provided by PseudoCAP

Function Evidence Code Pubs
enables DNA binding ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within mismatch repair ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
acts_upstream_of_or_within regulation of DNA recombination ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 

General protein information

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Preferred Names
DNA mismatch repair protein
NP_253633.1
  • Product name confidence: class 2 (High similarity to functionally studied protein)

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_002516.2 Reference assembly

    Range
    5549780..5551681 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_253633.1 DNA mismatch repair protein [Pseudomonas aeruginosa PAO1]

    See identical proteins and their annotated locations for NP_253633.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    Q9HUL8
    Conserved Domains (1) summary
    PRK00095
    Location:5 → 632
    mutL; DNA mismatch repair endonuclease MutL
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9HUL8.1

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