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thrH phosphoserine phosphatase [ Pseudomonas aeruginosa PAO1 ]

Gene ID: 877969, updated on 11-Sep-2024

Summary

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Gene symbol
thrH
Gene description
phosphoserine phosphatase
Locus tag
PA1757
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Pseudomonas aeruginosa PAO1 (strain: PAO1)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Pseudomonadales; Pseudomonadaceae; Pseudomonas
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Genomic context

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Sequence:
NC_002516.2 (1896630..1897247)

NC_002516.2Genomic Context describing neighboring genes Neighboring gene hypothetical protein Neighboring gene phosphoadenosine phosphosulfate reductase Neighboring gene para-aminobenzoate synthase component I Neighboring gene transcriptional regulator

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_002516.2

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Direct detection and kinetic analysis of covalent intermediate formation in the 4-amino-4-deoxychorismate synthase catalyzed reaction. He Z, et al. Biochemistry, 2006 Apr 18. PMID 16605270
  2. ThrH, a homoserine kinase isozyme with in vivo phosphoserine phosphatase activity in Pseudomonas aeruginosa. Patte JC, et al. Microbiology (Reading), 1999 Apr. PMID 10220164
  3. p-Aminobenzoate synthesis in Escherichia coli: purification and characterization of PabB as aminodeoxychorismate synthase and enzyme X as aminodeoxychorismate lyase. Ye QZ, et al. Proc Natl Acad Sci U S A, 1990 Dec. PMID 2251281, Free PMC Article
  4. The thrH gene product of Pseudomonas aeruginosa is a dual activity enzyme with a novel phosphoserine:homoserine phosphotransferase activity. Singh SK, et al. J Biol Chem, 2004 Mar 26. PMID 14699121
  5. Pseudomonas Genome Database: facilitating user-friendly, comprehensive comparisons of microbial genomes. Winsor GL, et al. Nucleic Acids Res, 2009 Jan. PMID 18978025, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by PseudoCAP

Function Evidence Code Pubs
enables 4-amino-4-deoxychorismate synthase activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables homoserine kinase activity IGI
Inferred from Genetic Interaction
more info
 PubMed 
enables magnesium ion binding ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables phosphoserine:homoserine phosphotransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within L-serine biosynthetic process IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within tetrahydrofolate biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
acts_upstream_of_or_within threonine biosynthetic process IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within threonine biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 

General protein information

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Preferred Names
phosphoserine phosphatase
NP_250448.1
  • Product name confidence: class 1 (Function experimentally demonstrated in P. aeruginosa)

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_002516.2 Reference assembly

    Range
    1896630..1897247
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_250448.1 phosphoserine phosphatase [Pseudomonas aeruginosa PAO1]

    See identical proteins and their annotated locations for NP_250448.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    Q9ZEX8
    Conserved Domains (1) summary
    PRK13582
    Location:1 → 205
    thrH; bifunctional phosphoserine phosphatase/homoserine phosphotransferase ThrH
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9I2Y2.1

Gene LinkOut

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Molecular Biology Databases