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ptxS transcriptional regulator PtxS [ Pseudomonas aeruginosa PAO1 ]

Gene ID: 877811, updated on 24-Aug-2024

Summary

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Gene symbol
ptxS
Gene description
transcriptional regulator PtxS
Locus tag
PA2259
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Pseudomonas aeruginosa PAO1 (strain: PAO1)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Pseudomonadales; Pseudomonadaceae; Pseudomonas
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Genomic context

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Sequence:
NC_002516.2 (2487856..2488878)

NC_002516.2Genomic Context describing neighboring genes Neighboring gene paerucumarin biosynthesis protein PvcC Neighboring gene paerucumarin biosynthesis protein PvcD Neighboring gene HTH-type transcriptional regulator PtxR Neighboring gene hypothetical protein Neighboring gene 2-ketogluconate kinase Neighboring gene 2-ketogluconate transporter

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_002516.2

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Transcriptional analysis of the Pseudomonas aeruginosa toxA regulatory gene ptxR. Colmer-Hamood JA, et al. Can J Microbiol, 2006 Apr. PMID 16699585
  2. The Pseudomonas aeruginosa global regulator MvaT specifically binds to the ptxS upstream region and enhances ptxS expression. Westfall LW, et al. Microbiology (Reading), 2004 Nov. PMID 15528665
  3. Genes for carbon metabolism and the ToxA virulence factor in Pseudomonas aeruginosa are regulated through molecular interactions of PtxR and PtxS. Daddaoua A, et al. PLoS One, 2012. PMID 22844393, Free PMC Article
  4. Pseudomonas Genome Database: facilitating user-friendly, comprehensive comparisons of microbial genomes. Winsor GL, et al. Nucleic Acids Res, 2009 Jan. PMID 18978025, Free PMC Article
  5. Defining the Pseudomonas aeruginosa SOS response and its role in the global response to the antibiotic ciprofloxacin. Cirz RT, et al. J Bacteriol, 2006 Oct. PMID 17015649, Free PMC Article

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. PtxS modulates PtxR activity in response to 2-ketogluconate by complex formation in solution in the case of the P(toxA) promoter, or via the formation of a DNA loop as in the regulation of gluconate catabolic genes
    Title: Genes for carbon metabolism and the ToxA virulence factor in Pseudomonas aeruginosa are regulated through molecular interactions of PtxR and PtxS.
  2. results suggest that MvaT positively regulates ptxS expression by binding specifically to the ptxS upstream region
    Title: The Pseudomonas aeruginosa global regulator MvaT specifically binds to the ptxS upstream region and enhances ptxS expression.
  3. Results indicate that negative regulation of ptxR expression by PtxS does not occur through the PtxS binding site within the ptxR-ptxS intergenic region.
    Title: Transcriptional analysis of the Pseudomonas aeruginosa toxA regulatory gene ptxR.
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by PseudoCAP

Process Evidence Code Pubs
acts_upstream_of_or_within negative regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
transcriptional regulator PtxS
NP_250949.1
  • Product name confidence: class 1 (Function experimentally demonstrated in P. aeruginosa)

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_002516.2 Reference assembly

    Range
    2487856..2488878
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_250949.1 transcriptional regulator PtxS [Pseudomonas aeruginosa PAO1]

    See identical proteins and their annotated locations for NP_250949.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A3M5ET15
    Conserved Domains (2) summary
    smart00354
    Location:12 → 82
    HTH_LACI; helix_turn _helix lactose operon repressor
    cd06283
    Location:72 → 333
    PBP1_RegR_EndR_KdgR-like; ligand-binding domain of DNA transcription repressor RegR and other putative regulators such as KdgR and EndR
Nucleotide Protein
Heading Accession and Version

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