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inaF-B inaF-B [ Drosophila melanogaster (fruit fly) ]

Gene ID: 8674114, updated on 4-Jan-2025

Summary

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Official Symbol
inaF-Bprovided by FlyBase
Official Full Name
inaF-Bprovided by FlyBase
Primary source
FLYBASE:FBgn0259918
Locus tag
Dmel_CG42447
See related
AllianceGenome:FB:FBgn0259918
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG42447; Dmel\CG42447; inaF; InaF; INAF; INAF-B
Summary
Enables calcium channel regulator activity. Involved in regulation of membrane potential in photoreceptor cell and response to light stimulus. Located in rhabdomere membrane. Part of inaD signaling complex. Is expressed in adult head. [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See inaF-B in Genome Data Viewer
Location:
10D8-10E1; 1-35 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (11724668..11732770, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (11618701..11626803, complement)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene pretaporter Neighboring gene Transport and Golgi organization 10 Neighboring gene uncharacterized protein Neighboring gene inaF-D Neighboring gene inaF-C Neighboring gene inaF-A Neighboring gene pseudo Neighboring gene miniature Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Drosophila TRP channels require a protein with a distinctive motif encoded by the inaF locus. Cheng Y, et al. Proc Natl Acad Sci U S A, 2007 Nov 6. PMID 17968007, Free PMC Article
  2. INAF, a protein required for transient receptor potential Ca(2+) channel function. Li C, et al. Proc Natl Acad Sci U S A, 1999 Nov 9. PMID 10557345, Free PMC Article
  3. Distinct TRP channels are required for warm and cool avoidance in Drosophila melanogaster. Rosenzweig M, et al. Proc Natl Acad Sci U S A, 2008 Sep 23. PMID 18787131, Free PMC Article
  4. Subcellular translocation of the eGFP-tagged TRPL channel in Drosophila photoreceptors requires activation of the phototransduction cascade. Meyer NE, et al. J Cell Sci, 2006 Jun 15. PMID 16735439, Free PMC Article
  5. Genetic effects in Drosophila on the potency of diverse general anesthetics: a distinctive pattern of altered sensitivity. Campbell JL, et al. J Neurogenet, 2009. PMID 19863272, Free PMC Article

See all (37) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. A Family of Auxiliary Subunits of the TRP Cation Channel Encoded by the Complex inaF Locus.
    Title: A Family of Auxiliary Subunits of the TRP Cation Channel Encoded by the Complex inaF Locus.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables calcium channel regulator activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in regulation of membrane potential in photoreceptor cell IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to light stimulus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of inaD signaling complex IPI
Inferred from Physical Interaction
more info
 PubMed 
located_in rhabdomere IDA
Inferred from Direct Assay
more info
 PubMed 
located_in rhabdomere membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
inaF-B
Names
CG42447-PA
inaF-B-PA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    11724668..11732770 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001169255.1 → NP_001162726.1  inaF-B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001162726.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A8WH76
    Conserved Domains (1) summary
    pfam15018
    Location:34 → 68
    InaF-motif; TRP-interacting helix
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A8WH76 A8WH76

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Other Literature Sources
Molecular Biology Databases
Research Materials