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Gyc76C Guanylyl cyclase at 76C [ Drosophila melanogaster (fruit fly) ]

Gene ID: 8674026, updated on 4-Jan-2025

Summary

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Official Symbol
Gyc76Cprovided by FlyBase
Official Full Name
Guanylyl cyclase at 76Cprovided by FlyBase
Primary source
FLYBASE:FBgn0266136
Locus tag
Dmel_CG42636
See related
AllianceGenome:FB:FBgn0266136
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG32215; CG42636; CG8742; DGC1; Dmel\CG42636; drgc; DrGC-1; gim; GYC 76C; gyc76C; l(3)76BDl; l(3)L0090
Old locus tag
Dmel_CG8742
Summary
Enables guanylate cyclase activity; peptide receptor activity; and semaphorin receptor binding activity. Involved in several processes, including axon guidance; larval somatic muscle development; and primary branching, open tracheal system. Located in plasma membrane. Is expressed in several structures, including adult brain; adult digestive system; germline cell; gut section; and larval muscle cell. [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See Gyc76C in Genome Data Viewer
Location:
76C3-76C5; 3-46 cM
Exon count:
20
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (19750943..19793569, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (19744043..19786669, complement)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Viral tegument-like deubiquitinase Neighboring gene Sterol regulatory element binding protein Neighboring gene uncharacterized protein Neighboring gene mir-33 stem loop Neighboring gene Ionotropic receptor 76a

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Identification, characterization, and developmental regulation of a receptor guanylyl cyclase expressed during early stages of Drosophila development. McNeil L, et al. J Biol Chem, 1995 Mar 31. PMID 7706258
  2. Molecular characterization of two Drosophila guanylate cyclases expressed in the nervous system. Liu W, et al. J Biol Chem, 1995 May 26. PMID 7759483
  3. Genetic, molecular and physiological basis of variation in Drosophila gut immunocompetence. Bou Sleiman MS, et al. Nat Commun, 2015 Jul 27. PMID 26213329, Free PMC Article
  4. Receptor-Type Guanylyl Cyclase at 76C (Gyc76C) Regulates De Novo Lumen Formation during Drosophila Tracheal Development. Myat MM, et al. PLoS One, 2016. PMID 27642749, Free PMC Article
  5. Function of the Drosophila receptor guanylyl cyclase Gyc76C in PlexA-mediated motor axon guidance. Chak K, et al. Development, 2014 Jan. PMID 24284209, Free PMC Article

See all (58) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. A Receptor Guanylate Cyclase, Gyc76C, Mediates Humoral, and Cellular Responses in Distinct Ways in Drosophila Immunity.
    Title: A Receptor Guanylate Cyclase, Gyc76C, Mediates Humoral, and Cellular Responses in Distinct Ways in Drosophila Immunity.
  2. These studies show that Gyc76C and downstream protein kinase G-dependent signaling regulate de novo lumen formation in the tracheal Dorsal trunk and terminal cells, most likely by affecting Arl3-mediated luminal secretion.
    Title: Receptor-Type Guanylyl Cyclase at 76C (Gyc76C) Regulates De Novo Lumen Formation during Drosophila Tracheal Development.
  3. We show that Gyc76C and the soluble cGMP-dependent kinase Foraging, likely linked by cGMP, are necessary for normal refinement and maintenance of long-range BMP signaling in the posterior crossvein
    Title: The Gyc76C Receptor Guanylyl Cyclase and the Foraging cGMP-Dependent Kinase Regulate Extracellular Matrix Organization and BMP Signaling in the Developing Wing of Drosophila melanogaster.
  4. Gyc76C genetically interacts with Semaphorin 1a and physically associates with the Sema-1a receptor plexin A.
    Title: Function of the Drosophila receptor guanylyl cyclase Gyc76C in PlexA-mediated motor axon guidance.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

mobile_element

  • Loc: c19776073-19771346 mobile_element_type = transposon:Doc{}1053

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables guanylate cyclase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables guanylate cyclase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables peptide receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables peptide receptor activity IPI
Inferred from Physical Interaction
more info
 PubMed 
enables phosphorus-oxygen lyase activity IEA
Inferred from Electronic Annotation
more info
  
NOT enables protein kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables semaphorin receptor binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables signaling receptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in axon guidance IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in axon midline choice point recognition IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in cGMP biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cyclic nucleotide biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in defense response to Gram-positive bacterium IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in extracellular matrix organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in larval somatic muscle development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in motor neuron axon guidance IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in primary branching, open tracheal system IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in receptor guanylyl cyclase signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in receptor guanylyl cyclase signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in receptor guanylyl cyclase signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of BMP signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to salt stress IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in salivary gland morphogenesis IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in salivary gland morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
guanylyl cyclase at 76C
Names
CG42636-PA
CG42636-PB
CG42636-PC
CG42636-PD
Gyc76C-PA
Gyc76C-PB
Gyc76C-PC
Gyc76C-PD
gimli
l(3)76BDl
lethal (3) L0090
receptor-type guanylate cyclase
NP_001163473.1
NP_001163474.1
NP_001163475.1
NP_001262063.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    19750943..19793569 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001170003.2 → NP_001163474.1  guanylyl cyclase at 76C, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001163474.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q24051, Q7JQ32
    UniProtKB/TrEMBL
    A4V243
    Conserved Domains (6) summary
    cd06370
    Location:26 → 445
    PBP1_Speract_GC_like; Ligand-binding domain of membrane bound guanylyl cyclases
    smart00044
    Location:860 → 1052
    CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
    cd14042
    Location:543 → 827
    PK_GC-A_B; Pseudokinase domain of the membrane Guanylate Cyclase receptors, GC-A and GC-B
    pfam00211
    Location:887 → 1074
    Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
    pfam01094
    Location:48 → 412
    ANF_receptor; Receptor family ligand binding region
    pfam07701
    Location:835 → 881
    HNOBA; Heme NO binding associated

  2. NM_001170004.2 → NP_001163475.1  guanylyl cyclase at 76C, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001163475.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q24051, Q7JQ32
    UniProtKB/TrEMBL
    A4V243
    Conserved Domains (6) summary
    cd06370
    Location:26 → 445
    PBP1_Speract_GC_like; Ligand-binding domain of membrane bound guanylyl cyclases
    smart00044
    Location:860 → 1052
    CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
    cd14042
    Location:543 → 827
    PK_GC-A_B; Pseudokinase domain of the membrane Guanylate Cyclase receptors, GC-A and GC-B
    pfam00211
    Location:887 → 1074
    Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
    pfam01094
    Location:48 → 412
    ANF_receptor; Receptor family ligand binding region
    pfam07701
    Location:835 → 881
    HNOBA; Heme NO binding associated

  3. NM_001275134.1 → NP_001262063.1  guanylyl cyclase at 76C, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001262063.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q24051, Q7JQ32
    UniProtKB/TrEMBL
    A4V243
    Conserved Domains (6) summary
    cd06370
    Location:26 → 445
    PBP1_Speract_GC_like; Ligand-binding domain of membrane bound guanylyl cyclases
    smart00044
    Location:860 → 1052
    CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
    cd14042
    Location:543 → 827
    PK_GC-A_B; Pseudokinase domain of the membrane Guanylate Cyclase receptors, GC-A and GC-B
    pfam00211
    Location:887 → 1074
    Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
    pfam01094
    Location:48 → 412
    ANF_receptor; Receptor family ligand binding region
    pfam07701
    Location:835 → 881
    HNOBA; Heme NO binding associated

  4. NM_001170002.1 → NP_001163473.1  guanylyl cyclase at 76C, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001163473.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q24051, Q7JQ32
    UniProtKB/TrEMBL
    A4V243
    Conserved Domains (6) summary
    cd06370
    Location:26 → 445
    PBP1_Speract_GC_like; Ligand-binding domain of membrane bound guanylyl cyclases
    smart00044
    Location:860 → 1052
    CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
    cd14042
    Location:543 → 827
    PK_GC-A_B; Pseudokinase domain of the membrane Guanylate Cyclase receptors, GC-A and GC-B
    pfam00211
    Location:887 → 1074
    Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
    pfam01094
    Location:48 → 412
    ANF_receptor; Receptor family ligand binding region
    pfam07701
    Location:835 → 881
    HNOBA; Heme NO binding associated
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7JQ32.1 Q7JQ32

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