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CG42542 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

Gene ID: 8674000, updated on 9-Dec-2024

Summary

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Official Symbol
CG42542provided by FlyBase
Official Full Name
uncharacterized proteinprovided by FlyBase
Primary source
FLYBASE:FBgn0260659
Locus tag
Dmel_CG42542
See related
AllianceGenome:FB:FBgn0260659
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG31303; CG4196; Dmel\CG42542
Old locus tag
Dmel_CG31303; Dmel_CG4196
Summary
Predicted to enable calcium ion transmembrane transporter activity and manganese ion transmembrane transporter activity. Predicted to be involved in Golgi calcium ion homeostasis and metal ion transport. Predicted to be active in Golgi apparatus. Is expressed in adult head. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation type IIk. Orthologous to human TMEM165 (transmembrane protein 165). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
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Genomic context

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See CG42542 in Genome Data Viewer
Location:
88E2-88E3; 3-56 cM
Exon count:
8
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (15196598..15203074)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (11022320..11028796)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Guanylyl cyclase at 88E Neighboring gene Myofilin Neighboring gene mir-3644 stem loop Neighboring gene Kip1 ubiquitination-promoting complex subunit 1 Neighboring gene Serpin 88Ea Neighboring gene Serpin 88Eb Neighboring gene Mau2 sister chromatid cohesion factor Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The Identification and Evolutionary Trends of the Solute Carrier Superfamily in Arthropods. Denecke SM, et al. Genome Biol Evol, 2020 Aug 1. PMID 32681801, Free PMC Article
  2. Iap2 is required for a sustained response in the Drosophila Imd pathway. Valanne S, et al. Dev Comp Immunol, 2007. PMID 17343912
  3. Isolation of gene sets affected specifically by polyglutamine expression: implication of the TOR signaling pathway in neurodegeneration. Nelson B, et al. Cell Death Differ, 2005 Aug. PMID 15861189
  4. The Genetic Basis for Variation in Sensitivity to Lead Toxicity in Drosophila melanogaster. Zhou S, et al. Environ Health Perspect, 2016 Jul. PMID 26859824, Free PMC Article
  5. A genetic interaction map of cell cycle regulators. Billmann M, et al. Mol Biol Cell, 2016 Apr 15. PMID 26912791, Free PMC Article

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables calcium ion transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables manganese ion transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in Golgi calcium ion homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in Golgi calcium ion transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in calcium ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in manganese ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
uncharacterized protein
Names
CG42542-PB
CG42542-PC
CG42542-PD
CG42542-PE
CG42542-PF
CG42542-PG

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    15196598..15203074
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001170143.2 → NP_001163614.1  uncharacterized protein Dmel_CG42542, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001163614.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    E1JIL1
    Conserved Domains (2) summary
    COG2119
    Location:97 → 183
    Gdt1; Putative Ca2+/H+ antiporter, TMEM165/GDT1 family [General function prediction only]
    pfam01169
    Location:423 → 492
    UPF0016; Uncharacterized protein family UPF0016

  2. NM_142169.4 → NP_650426.1  uncharacterized protein Dmel_CG42542, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_650426.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    C4XVE8, Q7KSI9
    Conserved Domains (1) summary
    COG2119
    Location:97 → 316
    Gdt1; Putative Ca2+/H+ antiporter, TMEM165/GDT1 family [General function prediction only]

  3. NM_001170145.2 → NP_001163616.1  uncharacterized protein Dmel_CG42542, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001163616.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    C4XVE8, Q7KSI9
    Conserved Domains (1) summary
    COG2119
    Location:97 → 316
    Gdt1; Putative Ca2+/H+ antiporter, TMEM165/GDT1 family [General function prediction only]

  4. NM_001170144.2 → NP_001163615.1  uncharacterized protein Dmel_CG42542, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001163615.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    E1JIL1
    Conserved Domains (2) summary
    COG2119
    Location:97 → 183
    Gdt1; Putative Ca2+/H+ antiporter, TMEM165/GDT1 family [General function prediction only]
    pfam01169
    Location:423 → 492
    UPF0016; Uncharacterized protein family UPF0016

  5. NM_170649.2 → NP_731978.1  uncharacterized protein Dmel_CG42542, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_731978.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    C4XVE8, Q7KSI9
    Conserved Domains (1) summary
    COG2119
    Location:97 → 316
    Gdt1; Putative Ca2+/H+ antiporter, TMEM165/GDT1 family [General function prediction only]

  6. NM_169620.2 → NP_731979.2  uncharacterized protein Dmel_CG42542, isoform G [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_731979.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    C5WLL7, Q8INE9
    Conserved Domains (2) summary
    COG2119
    Location:226 → 306
    Gdt1; Putative Ca2+/H+ antiporter, TMEM165/GDT1 family [General function prediction only]
    pfam01169
    Location:233 → 302
    UPF0016; Uncharacterized protein family UPF0016
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
E1JIL1 E1JIL1
Q7KSI9 Q7KSI9
Q8INE9 Q8INE9

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