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JHD1 [Histone H3]-lysine-36 demethylase [ Saccharomyces cerevisiae S288C ]

Gene ID: 856777, updated on 4-Jan-2025

Summary

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Official Symbol
JHD1
Official Full Name
[Histone H3]-lysine-36 demethylase
Primary source
SGD:S000000853
Locus tag
YER051W
See related
AllianceGenome:SGD:S000000853; FungiDB:YER051W; VEuPathDB:YER051W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
KDM2
Summary
Enables histone H3K36 demethylase activity and methylated histone binding activity. Involved in positive regulation of transcription elongation by RNA polymerase II. Predicted to be located in nucleus. Human ortholog(s) of this gene implicated in lung non-small cell carcinoma; melanoma; and syndromic X-linked intellectual disability Siderius type. Orthologous to several human genes including KDM2B (lysine demethylase 2B). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See JHD1 in Genome Data Viewer
Location:
chromosome: V
Exon count:
1
Sequence:
Chromosome: V; NC_001137.3 (254656..256134)

Chromosome V - NC_001137.3Genomic Context describing neighboring genes Neighboring gene oxidative DNA demethylase Neighboring gene mitochondrial 37S ribosomal protein RSM18 Neighboring gene aspartate kinase Neighboring gene Cu/Pi carrier

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001137.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The Saccharomyces cerevisiae histone demethylase Jhd1 fine-tunes the distribution of H3K36me2. Fang J, et al. Mol Cell Biol, 2007 Jul. PMID 17470555, Free PMC Article
  2. Site-specific Phosphorylation of Histone H3K36 Methyltransferase Set2p and Demethylase Jhd1p is Required for Stress Responses in Saccharomyces cerevisiae. Separovich RJ, et al. J Mol Biol, 2022 Apr 15. PMID 35183557
  3. Succinate inhibition of alpha-ketoglutarate-dependent enzymes in a yeast model of paraganglioma. Smith EH, et al. Hum Mol Genet, 2007 Dec 15. PMID 17884808
  4. Identification of histone demethylases in Saccharomyces cerevisiae. Tu S, et al. J Biol Chem, 2007 May 11. PMID 17369256, Free PMC Article
  5. Histone demethylation by a family of JmjC domain-containing proteins. Tsukada Y, et al. Nature, 2006 Feb 16. PMID 16362057

See all (28) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Site-specific Phosphorylation of Histone H3K36 Methyltransferase Set2p and Demethylase Jhd1p is Required for Stress Responses in Saccharomyces cerevisiae.
    Title: Site-specific Phosphorylation of Histone H3K36 Methyltransferase Set2p and Demethylase Jhd1p is Required for Stress Responses in Saccharomyces cerevisiae.
  2. Possible role for jhd1 enzyme, through inhibition by succinate in paraganglioma oncogenesis.
    Title: Succinate inhibition of alpha-ketoglutarate-dependent enzymes in a yeast model of paraganglioma.
  3. Jhd1 and Rph1 demethylate histone H3 Lys36 in transcribed regions to promote elongation
    Title: Two Saccharomyces cerevisiae JmjC domain proteins demethylate histone H3 Lys36 in transcribed regions to promote elongation.
  4. These studies establish Jhd1 as a histone demethylase in budding yeast and suggest that Jhd1 functions to maintain the fidelity of histone methylation patterns along transcription units.
    Title: The Saccharomyces cerevisiae histone demethylase Jhd1 fine-tunes the distribution of H3K36me2.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables dioxygenase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H3K36 demethylase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables histone H3K36 demethylase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables histone H3K36me/H3K36me2 demethylase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone demethylase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables methylated histone binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables transcription coregulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables zinc ion binding RCA
inferred from Reviewed Computational Analysis
more info
 PubMed 
Process Evidence Code Pubs
involved_in chromatin organization IEA
Inferred from Electronic Annotation
more info
  
involved_in chromatin remodeling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of transcription elongation by RNA polymerase II IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
[Histone H3]-lysine-36 demethylase
NP_010971.1
  • JmjC domain family histone demethylase specific for H3-K36; similar to proteins found in human, mouse, drosophila, X. laevis, C. elegans, and S. pombe

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001137.3 Reference assembly

    Range
    254656..256134
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001178942.1 → NP_010971.1  TPA: [Histone H3]-lysine-36 demethylase [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_010971.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D3DLV3, P40034
    UniProtKB/TrEMBL
    B3LS64, B5VHI4, C7GSK0, C8Z755
    Conserved Domains (2) summary
    smart00249
    Location:6 → 69
    PHD; PHD zinc finger
    smart00558
    Location:278 → 320
    JmjC; A domain family that is part of the cupin metalloenzyme superfamily
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P40034.1

Gene LinkOut

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